Plenity

Aka: Plenity

II. Indications

  1. Obesity (BMI 27 to 40)

III. Contraindications

  1. Abnormal gastrointestinal motility
  2. Altered Gastrointestinal Anatomy

IV. Mechanism

  1. Considered a medical device
  2. Capsule contains thousands of cellulose hydrogel beads
  3. 3 capsule dose (taken with water) expands in Stomach and reduces Stomach capacity for additional intake
  4. Particles are not absorbed (passed unchanged, unmetabolized into stool)

V. Dosing

  1. Plenity 3 capsules with 16 ounces water taken 20-30 min before lunch and before dinner
  2. Discontinue use if insignificant weight loss at 2 months

VI. Cost

  1. Estimated at $100 per month

VII. Adverse Effects

  1. Gastrointestinal (e.g. Flatulence, Abdominal Bloating)

VIII. Efficacy

  1. In 6 months of taking medication, results in 2% greater weight loss than Placebo
  2. Similar weight loss to Orlistat, but less weight loss than other medications (e.g. Phentermine, Qsymia)

IX. References

  1. (2020) Presc Lett 28(1): 3
  2. Greenway (2019) Obesity 27(2):205-216 +PMID:30421844 [PubMed]

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