II. Precautions
- No longer available in United States
- Due to significant adverse effects (See below)
- Included for historical information only
III. Adverse Effects: Evaluating for adverse cardiac effects
- Careful history and exam
-
Echocardiogram indications
- Symptoms suggestive of cardiopulmonary disease
- New onset murmur
- Consider for high patient anxiety
IV. Dosage
- Dosing: 15 mg bid (Historical reference only)
V. Mechanism
- D-Isomer of d,I-fenfluramine (Pondimin)
- Was used in combination with Phentermine (Ionamin)
- Combination was known as "Phen-Fen"
VI. Efficacy
- Obese patient over 6 months (n=822)
- Diet alone: 4.9 kg Weight Reduction
- Redux and Diet: 9.7 kg Weight Reduction
- Obese patients over 1 year (n=60)
- Diet alone: 7.2 kg Weight Reduction
- Redux and Diet: 9.8 kg Weight Reduction
- No difference from diet alone 5 months after treatment
VII. Adverse Effects
- Drowsiness
- Diarrhea
- Dry Mouth
-
Primary Pulmonary Hypertension
- Associated with use beyond 3 months
- Risk increased from 1 per Million to 18 per Million
- Obesity increases Pulmonary Hypertension risk 2 fold
- Valvular Heart Disease association
- New Heart Murmurs developed in 24 Phen-Fen Patients
- Mitral Regurgitation
- Aortic Insufficiency
- Tricuspid Regurgitation
- Occurred in women with over 1 year of Phen-Fen use
- References
- New Heart Murmurs developed in 24 Phen-Fen Patients