II. Background
- Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
- http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
- Although FDA Pregnancy Categories are no longer FDA designated, they are included here
- As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking
III. Category: Class A (No risk in controlled human studies)
- Dessicated Thyroid (Armour Thyroid)
- Levothyroxine (T4 or Synthroid)
- Liothyronine (T3 or Cytomel)
IV. Category: Class B (No risk in controlled animal studies)
V. Category: Class C (Small risk in controlled animal studies)
- Acetohexamide
- Beclomethasone
- Betamethasone
- Bromocriptine
- Chlorpropamide (Diabinase)
- Dexamethasone
- Glipizide (Glucotrol)
- Glyburide (Micronase or DiaBeta)
- Triamcinolone
VI. Category: Class D (Strong evidence of risk to the human fetus)
- Lynestrenol
- Medroxyprogesterone
- Methimazole
- Propylthiouracil (preferred over Methimazole)
- Tamoxifen
- Tolbutamide (Orinase)
VII. Category: Class X (Very high risk to the human fetus)
- Clomiphene (Clomid)
- Danazol
- Diethylstilbesterol (DES)
- Estrogens (all)
- Iodide I-131
- Leuprolide (Leupron)
- Norethindrone
- Norethynodrel
- Norgestrel
- Oral Contraceptives
VIII. References
- Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
- Larimore (2000) Prim Care 27(1):35-53 [PubMed]