II. Indications
- FDA Approved
- Endometriosis
- Fibrocystic Breast Disease
- Off-Label
III. Contraindications
- Hepatic Impairment
- Renal Impairment
- Cardiac dysfunction
- Pregnancy
IV. Mechanism
- Synthetic androgen derived from ethinyl Testosterone
- Inhibits gonadotropin (LH and FSH) secretion, resulting in decreased Estrogen secretion
- Danazol binds sex Hormone receptors in sensitive tissues
- Antiestrogenic and decreases Menstrual Bleeding
- Aanabolic and weakly androgenic (may affect voice)
V. Medications
- Danazol capsules: 50 mg, 100 mg, 200 mg
VI. Dosing
-
Endometriosis
- Start: 400 mg orally twice daily
- Titrate dose DOWN to lowest effective dose with goal Amenorrhea for 3-6 months (up to 9 months)
- Fibrocystic Breast Disease (or cyclical Mastalgia - off label use)
- Danazol 100 to 200 mg orally twice daily for up to 4 to 6 months
VII. Adverse Effects:
- Benign Intracranial Hypertension (Pseudotumor Cerebri)
- Peliosis hepatis
- Benign Hepatic Adenoma
- Androgenic Effects
- Acne Vulgaris
- Flushes
- Sweats
- Edema
- Libido changes
VIII. Safety
- Contraindicated in pregnancy (Pregnancy Category X)
- Associated with congenital abnormalities
- Use reliable non-Hormonal Contraception while taking Danazol (black box warning)
- Avoid in Lactation
IX. Efficacy
- Same rate of pregnancy as with Provera or Surgery
X. Drug Interactions
- Insulin
-
Warfarin
- Increased INR with concurrent Danazol
- Danazol increases other drug levels
-
Statins
- Increased risk of Statin-Induced Myopathy and Rhabdomyolysis
XI. Resources
Images: Related links to external sites (from Bing)
Related Studies
| danazol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DANAZOL 200 MG CAPSULE | Generic | $4.05 each |