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Definition (NCI)
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A synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.
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Definition (NCI_NCI-GLOSS)
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A synthetic form of the hormone estrogen that was prescribed to pregnant women between about 1940 and 1971 because it was thought to prevent miscarriages. Diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it. It also has been linked to an increased risk of clear cell carcinoma of the vagina or cervix in daughters exposed to diethylstilbestrol before birth.
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Definition (MSH)
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A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)
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Definition (CSP)
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synthetic nonsteroidal estrogen used in the treatment of menopausal, postmenopausal, and other disorders sensitive to estrogens; an epigenetic carcinogen.
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Definition (PDQ)
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DES; the acronym for diethylstilbestrol, a synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, DES inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43081&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43081&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C433" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
, Hormone
(T125)
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| MSH |
D004054
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| SnomedCT |
396026002, 79332009, 326185006, 327252004 |
| LNC |
LP18551-9, MTHU004623 |
| English |
Stilbestrol, diethylstilbestrol, Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, (E)-, Stilbestrol [gyn], Stilbestrol [malignancy], Stilboestrol [gyn], Stilboestrol [malignancy], Estrogen, Stilbene, 3,4-Bis(p-hydroxyphenyl)-3-hexene, 4,4'-Dihydroxy-alpha,beta-diethylstilbene, Alpha,alpha'-diethylstilbenediol, (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol, Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3, Stilbene Estrogen, stilbestrol, Diethylstilbestrolum, Diethylstilbenediol, Stilboestrol Dipropionate, Stilboestrol [gynaecological use], Stilbestrol [gynecological use], Diethylstilboestrol preparation, diethylstilbestrol (discontinued), diethylstilbestrol (discontinued) (medication), Diethylstilbestrol [Chemical/Ingredient], diethylstilbestrol (DES), Stilbestrol [gynecological use] (product), Diethylstilbestrol[malignancy], Stilbestrol [malignancy] (product), 3, 4-Bis(p-hydroxyphenyl)-3-hexene, DES, .alpha., .alpha.'-Diethylstilbenediol, Palestrol, 4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene, 3-Hexene,3,4-bis(p-hydroxyphenyl)-, DES preparation, Diethylstilbestrol preparation, Stilbestrol preparation, Stilboestrol, Diethylstilbestrol (substance), Diethylstilbestrol preparation (product), Diethylstilboestrol, Stilboestrol preparation, Diethylstilbestrol preparation (substance), Stilbestrol [gynecological use] (substance), Stilbestrol [malignancy] (substance), Diethylstilbestrol [gynaecological use], DIETHYLSTILBESTROL, Diethylstilbestrol |
| Portuguese |
Estilbestrol, Dietilestilbestrol |
| Spanish |
Estilbestrol, dietilestilbestrol (producto), preparado de dietilestilbestrol (producto), preparado de dietilestilbestrol, estilbestrol [uso ginecológico], estilbestrol [uso oncológico], estilbestrol [uso oncológico] (producto), estilbestrol [uso ginecológico] (producto), dietilestilbestrol (sustancia), dietilestilbestrol, preparado de DES, preparado de dietilestilbestrol (sustancia), preparado de estilbestrol, Dietilestilbestrol |
| Swedish |
Dietylstilbestrol
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| Czech |
diethylstilbestrol
|
| Finnish |
Dietyylistilbestroli
|
| Italian |
Estrogeno dello stilbene, Stilbestrolo, Dietilstilbestrolo |
| Russian |
STIL'BESTROL, DIETILSTIL'BESTROL, ДИЭТИЛСТИЛЬБЭСТРОЛ, СТИЛЬБЭСТРОЛ |
| Croatian |
DIETILSTILBESTROL
|
| Polish |
Dwuetylostilbestrol, Dietylostilbestrol, Stilbestrol |
| Japanese |
ジエチルスチルベストロール, エストロベン, スチルベストロール |
| French |
Diéthylstilbestrol
|
| German |
Diethylstilbestrol, Stilben (Östrogen) |
