II. Indications
-
Osteoporosis Prevention in postmenopausal women (Estraderm or Estrasorb)
- As of 2015, Estrogen is not recommended by ACOG or AAFP for chronic condition prevention
- Hot Flashes (Evanmist, Estrogel, Elestrin, Divigel)
III. Advantages
- Studies suggest no increased Thromboembolism risk
IV. Efficacy: Osteoporosis Prevention (Estraderm or Estrasorb)
-
Placebo
- Hip BMD: 2.04% loss
- Lumbar Spine BMD: 2.49% loss
- Dose: 0.025 mg Estradiol patch
- Hip BMD: 0.26% gain
- Lumbar Spine BMD: 2.37% gain
- Dose: 0.05 mg Estradiol patch
- Hip BMD: 2.85% gain
- Lumbar Spine BMD: 4.09% gain
- Dose: 0.06 mg Estradiol patch
- Hip BMD: 3.05% gain
- Lumbar Spine BMD: 3.28% gain
- Dose: 0.1 mg Estradiol patch
- Hip BMD: 2.03% gain
- Lumbar Spine BMD: 4.70% gain
- References
V. Preparations: Transdermal Combination Progesterone and Estrogen
- Activella (17B-Estradiol-Norethindrone Acetate)
- Contains 1 mg Estradiol with 0.5 mg Norethindrone
- Climara Pro (17B-Estradiol-Levonorgestrel)
- Patch contains 0.045 mg Estradiol with 0.015 Levonorgestrel
- Patch applied weekly
- Combipatch (17B-Estradiol-Norethindrone Acetate)
- Patch contains 0.05 mg Estradiol with 0.014 or 0.25 mg Norethindrone
- Patch applied twice weekly
VI. Preparations: Agents used for Osteoporosis (Transdermal Estradiol)
- Preparations must be taken with Progesterone if Uterus intact (Endometrial Hyperplasia risk)
- Estrasorb (Transdermal Estradiol)
- Estraderm (Transdermal Estradiol Patch)
VII. Preparations: Agents used for Menopausal Hot Flashes (Transdermal Estradiol)
- Preparations must be taken with Progesterone if Uterus intact (Endometrial Hyperplasia risk)
- Evanmist
- Dosing: 1-3 sprays per day on inner Forearm to adjacent areas (not overlapping)
- Allow skin to dry for 30 minutes
- Estrogel (0.06% Estradiol)
- Elestrin (0.06% Estradiol)
- Divigel (0.1% Estradiol)
- Foil packet delivers either 0.25 mg, 0.5 mg or 1.0 mg Estradiol per packet
- Apply packet contents to one upper thigh (5x7 inch area)
- Alternate to opposite side on subsequent application days
- Allow to dry for 1 hour before washing the area
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Related Studies
elestrin (on 3/15/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
ELESTRIN 0.06% GEL | $3.25 per gram | |
divigel (on 9/3/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
DIVIGEL 0.25 MG GEL PACKET | $5.41 each | |
DIVIGEL 0.5 MG GEL PACKET | $5.37 each | |
DIVIGEL 0.75 MG GEL PACKET | $5.41 each | |
DIVIGEL 1 MG GEL PACKET | $5.40 per gram | |
DIVIGEL 1.25 MG GEL PACKET | $4.31 per gram | |
minivelle (on 1/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
MINIVELLE 0.0375 MG PATCH | Generic | $6.51 each |
MINIVELLE 0.05 MG PATCH | Generic | $6.54 each |
MINIVELLE 0.075 MG PATCH | Generic | $6.43 each |
MINIVELLE 0.1 MG PATCH | Generic | $6.87 each |