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Definition (NCI)
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A derivative of the synthetic progestin norethindrone with antiprogesterone activity. Mifepristone competitively binds to the progesterone receptor, resulting in inhibition of the effects of endogenous or exogenous progesterone. This agent also exhibits antiglucocorticoid and weak antiandrogenic activities.
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Definition (NCI_NCI-GLOSS)
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A drug used to end early pregnancies. It is also being studied in the treatment of some types of cancer and other conditions. Mifepristone blocks the action of progesterone, a hormone that helps some cancers grow. It is a type of antiprogesterone.
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Definition (MSH)
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A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
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Definition (CSP)
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11-((4-dimethylamino) phenyl)-17-hydroxy-17-(1-propynyl) estra-4,9- dien-3-one; progesterone and glucocorticoid antagonist with potential applications in terminating pregnancy, controlling menstruation, and treating hypercortisolism.
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Definition (PDQ)
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A synthetic compound with antiprogesterone properties. Mifepristone competitively binds to the progesterone receptor, leading to changes in the endometrial blood supply. This agent also exhibits antiglucocorticoid and weak antiandrogenic activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40888&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40888&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C655" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Steroid
(T110)
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| MSH |
D015735
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| SnomedCT |
129483007, 326145000, 395796009 |
| English |
Mifepristone, mifepristone, Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11beta,17beta)-, (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, 11 Beta-[4-(N,N-dimethylamino)phenyl]-17alpha-(propyl-1-ynyl)-delta-4,9-estradiene-17 beta-ol-3-one, 11-((4-dimethylamino) phenyl)-17-Hydroxy-17-(1-propynyl) Estra-4,9- dien-3-one, Mifepristone product, progesterone inhibitors mifepristone (RU 486), mifepristone (medication), mifepristone (RU 486), Mifepristone [Chemical/Ingredient], MIFEPRISTONE, Mifepristone product (substance), Mifepristone (product), Mifepristone (substance) |
| Swedish |
Mifepriston
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| Czech |
mifepriston, RU-486 |
| Finnish |
Mifepristoni
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| Russian |
MIFEPRISTON, RU-486, МИФЕПРИСТОН |
| Japanese |
ミフェプリストン, ミフェギン |
| Polish |
Mifepryston
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| Spanish |
mifepristona (producto), mifepristona (sustancia), mifepristona, Mifepristona |
| French |
Mifépristone, Ru 486 |
| German |
Mifepriston
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| Italian |
Mifepristone
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| Portuguese |
Mifepristona
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