II. Dosing

  1. Amenorrhea
    1. Sequential: 5 to 10 mg qd for 5-10 days
    2. Continuous: 2.5 mg qd
  2. Dysfunctional Uterine Bleeding (DUB)
    1. Sequential: 5-10 mg qd for 5-10 days, start on Day 16
  3. Postmenopausal Estrogen Replacement (with Premarin)
    1. Sequential: 2.5 to 5 mg PO qd for last 10 cycle days
    2. Continuous: 5 to 10 mg qd

III. Adverse effects

  1. Major Depression
  2. Breakthrough bleeding
    1. Increasing dose to 20-30 mg qd may reduce bleeding
      1. However may have increased risk
      2. Long term lipid and cardiovascular effects?

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Related Studies

Cost: Medications

medroxyprogesterone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MEDROXYPROGESTERONE 10 MG TAB Generic $0.14 each
MEDROXYPROGESTERONE 150 MG/ML Generic $27.39 per ml
MEDROXYPROGESTERONE 2.5 MG TAB Generic $0.11 each
MEDROXYPROGESTERONE 5 MG TAB Generic $0.13 each