II. Definitions
- Tissue-selective Estrogen Complex (TSEC)
- Combination of Estrogen with a Selective Estrogen Receptor Modulator (SERM)
III. Indications
- Tissue-selective Estrogen Complex (TSEC)
- Estrogen Replacement Therapy in patients with an intact Uterus
IV. Background
- Duavee is the first Tissue-selective Estrogen Complex or TSEC (released in 2014)
- Duavee is a combination of Conjugated Estrogen with Bazedoxifene (SERM)
- Alternative to combination Estrogen with Progesterone
V. Efficacy
- Duavee (Conjugated Estrogen AND Bazedoxifene)
- Unclear role outside of cases of Estrogen Replacement with intact Uterus, in which Progesterone is contraindicated
- SERMs add potential for increased adverse effects with no added benefit when used in combination with Estrogen
- No additional bone protection in Osteoporosis
- Effective in decreasing vasomotor symptoms
- Significantly reduces vasomotor symptoms without affecting Breast tissue, endometrium or VTE or Cardiac Risk
- Lello (2017) Int J Endocrinol 2017:5064725 +PMID: 29358948 [PubMed]
VI. Medications
- Duavee (Conjugated Estrogen 0.45 mg with Bazedoxifene 20 mg)
- Take one tablet daily
VII. Adverse Effects
VIII. Resources
IX. References
- (2014) Presc Lett 21(3)
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Related Studies
| duavee (on 10/18/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DUAVEE 0.45-20 MG TABLET | $6.11 each | |