II. Indications
- Not generally recommended (no proven benefit and associated risk)
- Adjunct to Levothyroxine in Hypothyroidism
- Lethargy or memory deficits despite normal TSH
III. Adverse Effects
- Risk of Cardiovascular Risks when combined with Levothyroxine
IV. Efficacy
- May improve neuropsychiatric symptoms
- Changes after replacing T3 and T4
- Improved mood and energy
- Decreased confusion, fear, and irritability
- No difference in TSH normalization
- Studies suggests no benefit
V. Dosing (with Thyroxine dosing)
- Start: 1:14 ratio of Liothyronine to Levothyroxine (e.g. 5 mcg Liothyronine to 75 mcg Levothyroxine)
- Typical: 12.5 to 25 mcg orally daily
- Maximum: 100 ug orally daily
VI. References
- (2017) Presc Lett 25(1): 4
- Bunevicius (1999) N Engl J Med 340:424 [PubMed]
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Related Studies
liothyronine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
LIOTHYRONINE SOD 25 MCG TAB | Generic | $0.37 each |
LIOTHYRONINE SOD 5 MCG TAB | Generic | $0.29 each |
LIOTHYRONINE SOD 50 MCG TAB | Generic | $0.53 each |
cytomel (on 1/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
CYTOMEL 5 MCG TABLET | Generic | $0.29 each |