II. Indications
III. Dosing: Hyperprolactinemia
-
Bromocriptine (Parlodel)
- Larger safety database than Cabergoline (preferred in women trying to conceive)
- Start: 1.25 to 2.5 mg at bedtime
- Titrate: Increase by 2.5 mg every 3-7 days up to 15 mg daily
-
Cabergoline (Dostinex)
- Fewer side effects than Bromocriptine
- Start: 0.25 orally twice weekly
- Titrate: Increase by 0.25 mg every month up to 1 mg twice daily
IV. Dosing: Diabetes Mellitus 2
-
Bromocriptine QR or Cycloset
- Adjunctive with Metformin (and other Oral Hypoglycemic agents)
- Dosing
- Start 0.8 mg each am
- May increase up to weekly by 0.8 mg/day, to a maximum of 4.8 mg daily
- Efficacy
- May lower Hemoglobin A1C 0.7 to 1.4%
- References
- Joe Weidner, MD (2018) email communication, received 11/10/2018
- Gardner (2013) Endocr Pract 19(1):100-6 +PMID:23337160 [PubMed]
- Chamarthi (2017) Postgrad Med 129(4):446-455 +PMID:28374645 [PubMed]
V. Adverse Effects
- Nausea or Vomiting
- Postural Hypotension
- Dizziness
- Headache
- Sedation
- Valvular disorders
- Reported with high dose Cabergoline (>4 mg daily)