Definition (NCI)
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A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A drug that lessens inflammation and suppresses the body's immune response. It may also kill cancer cells. Prednisolone is used to treat disorders in many organ systems and to treat the symptoms of several types of leukemia and lymphoma. It is also being studied in the treatment of other types of cancer. Prednisolone is a type of therapeutic glucocorticoid.
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Definition (MSH)
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A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
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Definition (CSP)
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synthetic glucocorticoid with the general properties of the corticosteroids.
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Definition (PDQ)
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A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43296&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43296&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C769" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Steroid
(T110)
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MSH |
D011239
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SnomedCT |
317418003, 325425005, 116601002, 52388000 |
LNC |
LP18169-0, MTHU003522 |
English |
Prednisolone, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, Prednisolone [for preparations see rectal prednisolone], Prednisolone [see rectal pred], 1,2-Dehydrohydrocortisone, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, Metacortandralone, Delta(1)Hydrocortisone, Delta-F, Delta1-dehydro-hydrocortisone, Prednisolonum, Prednisolone [endocrine use], prednisolone (medication), PREDNISOLONE, Prednisolone [Chemical/Ingredient], prednisoLONE, Prednisolone [for preparations see rectal prednisolone] (product), Prednisolone [endocrine use] (product), .delta.1-Hydrocortisone, Deltahydrocortisone, Deltahydrocortisone preparation, Metacortandralone preparation, Prednisolone preparation, Prednisolone product, Prednisolone (substance), Prednisolone preparation (product), PRDL, Prednisolone [endocrine use] (substance), Prednisolone [for preparations see rectal prednisolone] (substance), Prednisolone preparation (substance), prednisolone, PrednisoLONE |
Swedish |
Prednisolon
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Czech |
prednisolon, depersolon |
Finnish |
Prednisoloni
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Russian |
DEPERZOLON, PREDNIZOLON, ДЕПЕРЗОЛОН, ПРЕДНИЗОЛОН |
Japanese |
プレドニソロン, デルポPD, ドニソロン, プレドニン, シエリゾロン, プレドニゾロン |
Spanish |
preparado con metacortandralona, preparado con prednisolona (producto), prednisolona (producto), preparado con deltahidrocortisona, preparado con prednisolona, prednisolona (uso endocrino), prednisolona (para preparaciones ver prednisolona rectal), prednisolona (uso endocrino) (producto), prednisolona (para preparaciones ver prednisolona rectal) (producto), prednisolona (sustancia), prednisolona, preparado de deltahidrocortisona, preparado de metacortandralona, preparado de prednisolona (producto), preparado de prednisolona (sustancia), preparado de prednisolona, Prednisolona |
Croatian |
PREDNIZOLON
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Polish |
Encortolon, Prednizolon |
French |
Prednisolone
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German |
Prednisolon
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Italian |
Prednisolone
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Portuguese |
Prednisolona
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