II. Background

  1. Sulfonylureas
    1. Sulfonylureas were first discovered in 1940's while investigating Sulfonamide antibiotics
    2. First Generation Sulfonylureas (e.g. Tolbutamide) were developed in the 1960s
    3. Second Generation Sulfonylureas were available in the 1980s
    4. Sulfonylureas are also used as herbicides (block specific plant Amino Acid biosynthesis)
  2. Meglitinides
    1. Meglitinide development started in the 1970s and were marketed in the U.S. in the late 1990s

III. Mechanism

  1. Sulfonylureas stimulate Potassium channel closure on pancreatic beta cell surface
    1. Triggers Insulin release

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