Insulin Glargine U-300

Aka: Insulin Glargine U-300, Toujeo, Toujeo Max Solostar

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II. Indications

  1. Similar indications to standard Insulin Glargine concentration (100 units/ml)
    1. Promoted as a longer acting Lantus (closer to 24 hour duration) at several fold higher cost
    2. However, in practice, U-300 likely adds little benefit over standard Insulin Glargine
  2. Type 1 Diabetes Mellitus
    1. Basal insulin for those not using an Insulin Pump (or for emergency use when Insulin Pump fails)
  3. Type 2 Diabetes Mellitus with Insulin Resistance refractory to non-Insulin therapy

III. Medications

  1. Toujeo Solostar pen
    1. Toujeo contains 80 units/injection (450 u/pen)
    2. Toujeo Max contains 160 units/injection (900 u/pen)
    3. Both contain the same 3x GlargineInsulin concentration of Lantus)

IV. Pharmacokinetics

  1. Onset: 6 hours
  2. Duration: 24 to 36 hours
  3. Released in 2015 (curiously as Lantus becomes generic)
    1. Promoted as a longer acting Lantus (closer to 24 hour duration)
    2. However, more expensive ($500/month if 60 u/day); contrast with NPH at 10% of cost

V. Dosing

  1. See Insulin Dosing
  2. See Insulin Dosing in Type I Diabetes
  3. See Insulin Dosing in Type II Diabetes
  4. Insulin Glargine U-300 is injected subcutaneously
  5. Do not adjust Toujeo dose more often than every 3-4 days
  6. Insulin Naive Starting Dose in Type 2 Diabetes Mellitus: 0.2 units/kg SQ daily
  7. Transitioning from other agents
    1. From Lantus, Basaglar daily
      1. Dose Toujeo at 110% of Lantus dose
    2. From Lantus twice daily
      1. Dose Toujeo at 100% of the Lantus dose
    3. From Detemir or NPH twice daily
      1. Dose Toujeo at 80% of total daily Basal insulin dose
  8. Transitioning to other agents
    1. To Lantus or Basaglar
      1. Dose Lantus or Basaglar at 80% of Toujeo dose to start, then titrate up

VI. Adverse Effects

  1. See Insulin

VII. Safety

  1. Insulin is considered safe in pregnancy and Lactation

VIII. References

  1. (2018) Presc Lett 25(8)
  2. Riddle (2014) Diabetes Care 37(10):2755-62 +PMID:25078900 [PubMed]

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Related Studies

Cost: Medications

toujeo (on 4/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TOUJEO MAX SOLOSTR 300 UNIT/ML $82.96 per ml
TOUJEO SOLOSTAR 300 UNIT/ML $82.93 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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