II. Indications
III. Mechanism
- See Systemic Corticosteroid
- Cortisone is a naturally occurring steroid Hormone produced in the Adrenal Gland
- Cortisone is hydroxylated to the active Cortisol by the enzyme 11-beta-steroid dehydrogenase
IV. Medications
- Cortisone (Cortone) tablets 25 mg
V. Dosing: Adrenal Insufficiency
- Adult: 25 to 300 mg orally daily
- Child (not FDA approved): 0.5 to 0.75 mg/kg/day orally divided every 8 hours
VI. Pharmacokinetics
- Low potency
- Low anti-inflammatory potency
- Has Mineralocorticoid Activity
- Short Half-Life (8-12 hours)
VII. Adverse Effects
VIII. Safety
- See Systemic Corticosteroid
- Pregnancy Category D
- Avoid in Lactation
IX. References
- Swadron and Hope in Herbert (2018) EM:Rap 18(9):16-8
- Dvorin (2020) Am Fam Physician 101(2): 89-94 [PubMed]
- Lane (1998) Endocrinol Metab Clin North Am 27:465-83 [PubMed]