II. Indications

III. Mechanism

  1. See Systemic Corticosteroid
  2. Cortisone is a naturally occurring steroid Hormone produced in the Adrenal Gland
  3. Cortisone is hydroxylated to the active Cortisol by the enzyme 11-beta-steroid dehydrogenase

IV. Medications

  1. Cortisone (Cortone) tablets 25 mg

V. Dosing: Adrenal Insufficiency

  1. Adult: 25 to 300 mg orally daily
  2. Child (not FDA approved): 0.5 to 0.75 mg/kg/day orally divided every 8 hours

VI. Pharmacokinetics

  1. Low potency
  2. Low anti-inflammatory potency
  3. Has Mineralocorticoid Activity
  4. Short Half-Life (8-12 hours)

VII. Adverse Effects

VIII. Safety

  1. See Systemic Corticosteroid
  2. Pregnancy Category D
  3. Avoid in Lactation

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Ontology: Cortisone (C0010137)

Definition (NCI_NCI-GLOSS) A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory. Cortisone reduces swelling and can suppress immune responses.
Definition (NCI) A corticosteroid with potent glucocorticoid activity. Therapeutic cortisone is the inactive precursor molecule of the active hormone cortisol, which is the hydroxylation product of cortisone by 11-beta-steroid dehydrogenase. Cortisol increases blood pressure and blood sugar levels, and suppresses the immune system, therefore cortisone is used to treat allergies or inflammation.
Definition (NCI) A steroid hormone synthesized and secreted by the adrenal gland and necessary for life. It is involved with maintaining cardiovascular function, blood glucose balance, regulating the inflammatory response and metabolism of proteins, carbohydrates, and fat.
Definition (MSH) A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Definition (CSP) naturally occurring glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent; cortisone itself is inactive and is converted in the liver to the active metabolite cortisol.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D003348
SnomedCT 32498003, 111150008
LNC LP18544-4, LP157319-7, MTHU004611
English cortisone, Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 17,21-Dihydroxypregn-4-ene-3,11,20-trione, Cortisone, Cortisone [Chemical/Ingredient], cortisones, CORTISONE, Compound E, Cortisone preparation, Cortisone (substance), Cortisone preparation (product), Cortisone product, CORT, Cortisone preparation (substance), Therapeutic Cortisone
Swedish Kortison
Czech kortison
Finnish Kortisoni
Russian KORTIZON, КОРТИЗОН
Japanese コルチゾン, 11-デヒドロ-17-ヒドロキシコルチコステロン
Spanish preparado con cortisona (producto), cortisona (producto), preparado con cortisona, cortisona (sustancia), cortisona, preparado de cortisona (producto), preparado de cortisona (sustancia), preparado de cortisona, Cortisona
Croatian KORTIZON
Polish Kortyzon
Norwegian Kortison
French Cortisone
German Cortison
Italian Cortisone
Portuguese Cortisona