First Generation Sulfonylurea

Aka: First Generation Sulfonylurea, Tolbutamide, Tolazamide, Chlorpropamide, Acetohexamide

advertisement

II. Background

  1. Listed for historical purposes only
  2. See Second Generation Sulfonylurea instead

III. Indications

  1. Type II Diabetes Mellitus (historical)
    1. Replaced by Second Generation Sulfonylurea agents

IV. Mechanism

  1. Sulfonylureas trigger Insulin release from pancreatic beta cells
    1. Sulfonylureas stimulate Potassium channel closure on pancreatic beta cell surface
    2. Secretagogues do NOT burn out the beta cells sooner
  2. Sulfonylureas may also increase tissue Insulin sensitivity

V. Medications

  1. Acetohexamide (Dymelor)
    1. Dose: 500 to 750 mg orally daily or divided twice daily
  2. Chlorpropamide (Diabinese)
    1. Dose: 100 to 250 mg up to 750 mg daily or divided twice daily
    2. Antidiuretic effect (used in Diabetes Insipidus)
  3. Tolazamide (Tolinase)
    1. Dose: 250-500 mg orally daily or divided twice daily
  4. Tolbutamide (Orinase)
    1. Dose: 1000 to 2000 mg orally daily or divided twice daily

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "First Generation Sulfonylurea." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Studies

Related Topics in Pharmacology

advertisement