II. Medications

  1. Chewable Tablets: 100 mg
    1. In U.S., Vermox was original trade name (in 2016 was rebranded as Enverm)

III. Indications

IV. Mechanism

  1. Synthetic benzimidazole derivate
  2. Inhibits Helminth (worm) reproduction and survival
    1. Blocks microtubule formation (polymerization) in cytoplasm
    2. Blocks Glucose uptake and depletes Helminth glycogen stores
    3. Results in reduced ATP and Helminth death

V. Dosing: Adults and Children

  1. Doses for adults and children are the same
  2. Pinworm
    1. Mebendazole 100 mg orally for a single dose, and repeat in 2 weeks
  3. Roundworm, Hookworm or Whipworm
    1. Mebendazole 100 mg orally twice daily for 3 days OR
    2. Mebendazole 500 mg orally twice daily for one dose (off label)

VI. Safety

  1. Unknown safety in first trimester (may be used in later pregnancy)
  2. Considered safe in Lactation

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Related Studies

Cost: Medications

emverm (on 2/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
EMVERM 100 MG TABLET CHEW $538.55 each

Ontology: Mebendazole (C0025023)

Definition (NCI) A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.
Definition (MSH) A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008463
SnomedCT 387311004, 56059005
English Mebendazole, Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester, mebendazole, (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester, Methyl 5-benzoyl benzimidazole-2-carbamate, mebendazole (medication), MEBENDAZOLE, Mebendazole [Chemical/Ingredient], Mebendazole product, Mebendazole (product), Mebendazole (substance)
Swedish Mebendazol
Czech mebendazol
Finnish Mebendatsoli
Russian MEBENDAZOL, VERMOKS, ВЕРМОКС, МЕБЕНДАЗОЛ
Japanese メベンダゾール, ベルモックス
Croatian MEBENDAZOL
Polish Mebendazol
Spanish mebendazol (producto), mebendazol (sustancia), mebendazol, Mebendazol
French Mébendazole
German Mebendazol
Italian Mebendazolo
Portuguese Mebendazol