II. Activity Spectrum (See Class I and Class II below)
- Gram Negative Rod coverage (see other Fluoroquinolones)
- Some atypical Bacteria coverage (Class II only)
- See Ciprofloxacin below for other activity
III. Preparations: Class I
- Indications
- Uncomplicated Urinary Tract Infections
- Similar spectrum to first generation agents
- Improved Gram Negative coverage over first generation
- Low systemic drug concentrations
- Agents
- Lomefloxacin (Maxaquin)
- Enoxacin (Penetrex)
- Norfloxacin (Noroxin)
IV. Preparations: Class II
- Indications
- Complicated Urinary Tract Infections
- Specific types of Bacterial Gastroenteritis
- Prostatitis
- Sexually Transmitted Disease
- Avoid in Community Acquired Pneumonia
- Risk of pneumococcal bacteremia and Meningitis
- Additional Indications for Ciprofloxacin
- Pseudomonas Aeruginosa
- Bacillus anthracis or Anthrax (first line agent)
- Vibrio Cholerae (Norfloxacin also covers)
- Yersinia Pestis or Plague (first line agent)
- Tularemia (alternative medication)
- Significantly more active than Class I agents
- Broader Gram Negative coverage than Class I agents
- High systemic drug concentrations
- Some atypical Bacteria coverage
- Pseudomonas Aeruginosa (Ciprofloxacin only)
- Agents
V. Directions
- Take on an empty Stomach
- Take more than 1 hour before or two hours after food
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| Definition (NCI) | A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA replication. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic gram-positive and gram-negative organisms. |
| Definition (MSH) | A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D009643 |
| SnomedCT | 330406001, 387271008, 49485009 |
| LNC | LP16156-9, MTHU008461 |
| English | Norfloxacin, 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Norfloxacin [eye], 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, norfloxacin, norfloxacin (medication), norfloxacin ophthalmic, Norfloxacin [Chemical/Ingredient], Norfloxacin [eye] (product), Norfloxacin (product), Norfloxacin (substance), Norfloxacin [eye] (substance), NORFLOXACIN |
| Swedish | Norfloxacin |
| Czech | norfloxacin |
| Finnish | Norfloksasiini |
| Russian | NORFLOKSATSIN, НОРФЛОКСАЦИН |
| Japanese | ノルフロキサシン |
| Spanish | norfloxacino, norfloxacino (producto), norfloxacina, norfloxacina (producto), norfloxacino (sustancia), norfloxacina [uso oftálmico] (producto), norfloxacina [uso oftálmico], norfloxacina (sustancia), norfloxacina [oftálmica] (producto), norfloxacina [oftálmica], Norfloxacino |
| Polish | Norfloksacyna |
| French | Norfloxacine |
| German | Norfloxacin |
| Italian | Norfloxacina |
| Portuguese | Norfloxacino |
