II. Activity Spectrum (See Class I and Class II below)
- Gram Negative Rod coverage (see other Fluoroquinolones)
- Some atypical Bacteria coverage (Class II only)
- See Ciprofloxacin below for other activity
III. Preparations: Class I
- Indications
- Uncomplicated Urinary Tract Infections
- Similar spectrum to first generation agents
- Improved Gram Negative coverage over first generation
- Low systemic drug concentrations
- Agents
- Lomefloxacin (Maxaquin)
- Enoxacin (Penetrex)
- Norfloxacin (Noroxin)
IV. Preparations: Class II
- Indications
- Complicated Urinary Tract Infections
- Specific types of Bacterial Gastroenteritis
- Prostatitis
- Sexually Transmitted Disease
- Avoid in Community Acquired Pneumonia
- Risk of pneumococcal bacteremia and Meningitis
- Additional Indications for Ciprofloxacin
- Pseudomonas aeruginosa
- Bacillus anthracis or Anthrax (first line agent)
- Vibrio Cholerae (Norfloxacin also covers)
- Yersinia pestis or Plague (first line agent)
- Tularemia (alternative medication)
- Significantly more active than Class I agents
- Broader Gram Negative coverage than Class I agents
- High systemic drug concentrations
- Some atypical Bacteria coverage
- Pseudomonas aeruginosa (Ciprofloxacin only)
- Agents
V. Directions
- Take on an empty Stomach
- Take more than 1 hour before or two hours after food