II. Activity Spectrum (See Class I and Class II below)
- Gram Negative Rod coverage (see other Fluoroquinolones)
- Some atypical Bacteria coverage (Class II only)
- See Ciprofloxacin below for other activity
III. Preparations: Class I
- Indications
- Uncomplicated Urinary Tract Infections
- Similar spectrum to first generation agents
- Improved Gram Negative coverage over first generation
- Low systemic drug concentrations
- Agents
- Lomefloxacin (Maxaquin)
- Enoxacin (Penetrex)
- Norfloxacin (Noroxin)
IV. Preparations: Class II
- Indications
- Complicated Urinary Tract Infections
- Specific types of Bacterial Gastroenteritis
- Prostatitis
- Sexually Transmitted Disease
- Avoid in community acquired Pneumonia
- Risk of pneumococcal bacteremia and Meningitis
- Additional Indications for Ciprofloxacin
- Pseudomonas aeruginosa
- Bacillus anthracis or Anthrax (first line agent)
- Vibrio Cholerae (Norfloxacin also covers)
- Yersinia pestis or Plague (first line agent)
- Tularemia (alternative medication)
- Significantly more active than Class I agents
- Broader Gram Negative coverage than Class I agents
- High systemic drug concentrations
- Some atypical Bacteria coverage
- Pseudomonas aeruginosa (Ciprofloxacin only)
- Agents
- Ciprofloxacin (Cipro)
- Ofloxacin (Floxin)
V. Directions
- Take on an empty Stomach
- Take more than 1 hour before or two hours after food
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| Ciprofloxacin (on 6/18/2017 at Walmart.com) | ||
| Ciprofloxacin 250mg | #14 tablets for $4.00 | $0.29 each |
| Ciprofloxacin 250mg | #42 tablets for $10.00 | $0.24 each |
| Ciprofloxacin 500mg | #20 tablets for $4.00 | $0.20 each |
| Ciprofloxacin 500mg | #60 tablets for $10.00 | $0.17 each |
| ciprofloxacin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CIPROFLOXACIN 0.2% OTIC SOLN | Generic | $6.19 each |
| CIPROFLOXACIN 0.3% EYE DROP | Generic | $1.28 per ml |
| CIPROFLOXACIN HCL 250 MG TAB | Generic | $0.12 each |
| CIPROFLOXACIN HCL 500 MG TAB | Generic | $0.15 each |
| CIPROFLOXACIN HCL 750 MG TAB | Generic | $0.27 each |
| ofloxacin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| OFLOXACIN 0.3% EAR DROPS | Generic | $10.63 per ml |
| OFLOXACIN 0.3% EYE DROPS | Generic | $2.93 per ml |
Ontology: Ciprofloxacin (C0008809)
| Definition (CHV) | a drug used to treat a cancer as well as an infection |
| Definition (NCI) | A synthetic broad spectrum fluoroquinolone antibiotic. Ciprofloxacin binds to and inhibits bacterial DNA gyrase, an enzyme essential for DNA replication. This agent is more active against Gram-negative bacteria than Gram-positive bacteria. (NCI04) |
| Definition (NCI_NCI-GLOSS) | A drug that is used to treat infections caused by bacteria and is being studied in the treatment of bladder cancer. Cipro is a type of fluoroquinolone. |
| Definition (CSP) | broad spectrum antimicrobial carboxyfluoroquinoline. |
| Definition (MSH) | A broad-spectrum antimicrobial carboxyfluoroquinoline. |
| Definition (PDQ) | A synthetic broad spectrum fluoroquinolone antibiotic. Ciprofloxacin binds to and inhibits bacterial DNA gyrase, an enzyme essential for DNA replication. This agent is more active against Gram-negative bacteria than Gram-positive bacteria. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40784&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40784&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C375" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D002939 |
| SnomedCT | 392412000, 330416009, 372840008, 7577004 |
| LNC | LP15380-6, MTHU004599 |
| English | Ciprofloxacin, 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Ciprofloxacin [eye], 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Ciprofloxacin ophthalmic preparation, Ciprofloxacin ophthalmic preparation (product), ciprofloxacin, Ciprofloxacin opthalmic preparation (product), Ciprofloxacin opthalmic preparation, CIPROFLOXACIN, ciprofloxacin (medication), Ciprofloxacin [Chemical/Ingredient], Ciprofloxacin [eye] (product), Ciprofloxacin product, Ciprofloxacin (product), Ciprofloxacin (substance), CPFX, Ciprofloxacin [eye] (substance) |
| Swedish | Ciprofloxacin |
| Czech | ciprofloxacin |
| Finnish | Siprofloksasiini |
| Russian | TSIPROFLOKSATSIN, ЦИПРОФЛОКСАЦИН |
| Croatian | CIPROFLOKSACIN |
| Spanish | ciprofloxacina, ciprofloxacina (producto), ciprofloxacino, ciprofloxacino (producto), ciprofloxacino (sustancia), ciprofloxacina [uso oftálmico], ciprofloxacina [uso oftálmico] (producto), ciprofloxacina (sustancia), ciprofloxacina [oftálmica] (producto), ciprofloxacina [oftálmica], ciprofloxacina, preparado oftálmico (producto), ciprofloxacina, preparado oftálmico, preparado oftálmico con ciprofloxacina (producto), preparado oftálmico con ciprofloxacina, Ciprofloxacino |
| Polish | Cyprofloksacyna, Ciprofloksacyna |
| Japanese | シプロフロキサシン, シプロキサン, 塩酸シプロフロキサシン, シプロフロキサシン塩酸塩 |
| Portuguese | Ciprofloxacina, Ciprofloxacino |
| French | Ciprofloxacine |
| German | Ciprofloxacin |
| Italian | Ciproflossacina |
Ontology: Norfloxacin (C0028365)
| Definition (NCI) | A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA replication. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic gram-positive and gram-negative organisms. |
| Definition (MSH) | A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D009643 |
| SnomedCT | 330406001, 387271008, 49485009 |
| LNC | LP16156-9, MTHU008461 |
| English | Norfloxacin, 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Norfloxacin [eye], 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, norfloxacin, norfloxacin (medication), norfloxacin ophthalmic, Norfloxacin [Chemical/Ingredient], Norfloxacin [eye] (product), Norfloxacin (product), Norfloxacin (substance), Norfloxacin [eye] (substance), NORFLOXACIN |
| Swedish | Norfloxacin |
| Czech | norfloxacin |
| Finnish | Norfloksasiini |
| Russian | NORFLOKSATSIN, НОРФЛОКСАЦИН |
| Japanese | ノルフロキサシン |
| Spanish | norfloxacino, norfloxacino (producto), norfloxacina, norfloxacina (producto), norfloxacino (sustancia), norfloxacina [uso oftálmico] (producto), norfloxacina [uso oftálmico], norfloxacina (sustancia), norfloxacina [oftálmica] (producto), norfloxacina [oftálmica], Norfloxacino |
| Polish | Norfloksacyna |
| French | Norfloxacine |
| German | Norfloxacin |
| Italian | Norfloxacina |
| Portuguese | Norfloxacino |
