II. Activity Spectrum (See Class I and Class II below)
- Gram Negative Rod coverage (see other Fluoroquinolones)
- Some atypical Bacteria coverage (Class II only)
- See Ciprofloxacin below for other activity
III. Preparations: Class I
- Indications
- Uncomplicated Urinary Tract Infections
- Similar spectrum to first generation agents
- Improved Gram Negative coverage over first generation
- Low systemic drug concentrations
- Agents
- Lomefloxacin (Maxaquin)
- Enoxacin (Penetrex)
- Norfloxacin (Noroxin)
IV. Preparations: Class II
- Indications
- Complicated Urinary Tract Infections
- Specific types of Bacterial Gastroenteritis
- Prostatitis
- Sexually Transmitted Disease
- Avoid in Community Acquired Pneumonia
- Risk of pneumococcal bacteremia and Meningitis
- Additional Indications for Ciprofloxacin
- Pseudomonas aeruginosa
- Bacillus anthracis or Anthrax (first line agent)
- Vibrio Cholerae (Norfloxacin also covers)
- Yersinia pestis or Plague (first line agent)
- Tularemia (alternative medication)
- Significantly more active than Class I agents
- Broader Gram Negative coverage than Class I agents
- High systemic drug concentrations
- Some atypical Bacteria coverage
- Pseudomonas aeruginosa (Ciprofloxacin only)
- Agents
- Ciprofloxacin (Cipro)
- Ofloxacin (Floxin)
V. Directions
- Take on an empty Stomach
- Take more than 1 hour before or two hours after food
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Related Studies
| ciprofloxacin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CIPROFLOXACIN 0.2% OTIC SOLN | Generic | $6.34 each |
| CIPROFLOXACIN 0.3% EYE DROP | Generic | $1.74 per ml |
| CIPROFLOXACIN HCL 250 MG TAB | Generic | $0.10 each |
| CIPROFLOXACIN HCL 500 MG TAB | Generic | $0.15 each |
| CIPROFLOXACIN HCL 750 MG TAB | Generic | $0.21 each |
| ofloxacin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| OFLOXACIN 0.3% EAR DROPS | Generic | $1.89 per ml |
| OFLOXACIN 0.3% EYE DROPS | Generic | $1.69 per ml |