II. Indications: Severe Gram Positive Infections

III. Mechanism

  1. Bacterial 50S Ribosome
  2. Resistance rare

IV. Pharmacokinetics

  1. Hepatic clearance predominates
  2. Half-life: 1-3 hours (9-10 hours of affect)

V. Adverse Effects

  1. Arthralgias or myalgias
  2. Nausea, Diarrhea or Vomiting
  3. Rash or Pruritus
  4. Headache

VI. Drug Interactions: Metabolized by Cytochrome P-450 3A4

  1. Raises serum drug levels of substrates in 3A4 system
  2. Follow Cyclosporine levels when using concurrently

VII. Dosing

  1. Enterococcus faecium: 7.5 mg/kg IV q8 hours
  2. Severe Skin Infections: 7.5 mg/kg IV q12 hours

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Ontology: Streptogramins (C0205997)

Definition (MSH) A class of natural cyclic peptide antibiotics produced by certain subspecies of STREPTOMYCES. They include two structurally unrelated components, STREPTOGRAMIN GROUP A and STREPTOGRAMIN GROUP B, which generally act synergistically to inhibit bacterial growth.
Concepts Antibiotic (T195) , Amino Acid, Peptide, or Protein (T116)
MSH D025361
SnomedCT 420946006, 422292008
English Streptogramins, Streptogramin, Streptogramin (product), Streptogramin (substance), Streptogramins [Chemical/Ingredient], streptogramin, streptogramins
Spanish estreptogramina (producto), estreptogramina (sustancia), estreptogramina, Estreptograminas
Swedish Streptograminer
Czech streptograminy
Finnish Streptogramiinit
French Streptogramine, Streptogramines, Synergystines
Japanese ストレプトグラミン
Italian Steptogramina, Steptogramine
Polish Streptograminy
German Streptogramine
Portuguese Estreptograminas

Ontology: Synercid (C0526512)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C062940
English Synercid, synercid