II. Indications: Severe Gram Positive Infections
- Vancomycin-resistant Enterococcus
- Methicillin susceptible Staphylococcus Aureus
- Methicillin susceptible Streptococcus Pyogenes
III. Mechanism
- Bacterial 50S Ribosome
- Resistance rare
IV. Pharmacokinetics
- Hepatic Clearance predominates
- Half-Life: 1-3 hours (9-10 hours of affect)
VI. Drug Interactions: Metabolized by Cytochrome P-450 3A4
- Raises serum drug levels of substrates in 3A4 system
- Follow Cyclosporine levels when using concurrently
VII. Dosing
- Enterococcus faecium: 7.5 mg/kg IV q8 hours
- Severe Skin Infections: 7.5 mg/kg IV q12 hours
Images: Related links to external sites (from Bing)
Related Studies
Definition (MSH) | A class of natural cyclic peptide antibiotics produced by certain subspecies of STREPTOMYCES. They include two structurally unrelated components, STREPTOGRAMIN GROUP A and STREPTOGRAMIN GROUP B, which generally act synergistically to inhibit bacterial growth. |
Concepts | Antibiotic (T195) , Amino Acid, Peptide, or Protein (T116) |
MSH | D025361 |
SnomedCT | 420946006, 422292008 |
English | Streptogramins, Streptogramin, Streptogramin (product), Streptogramin (substance), Streptogramins [Chemical/Ingredient], streptogramin, streptogramins |
Spanish | estreptogramina (producto), estreptogramina (sustancia), estreptogramina, Estreptograminas |
Swedish | Streptograminer |
Czech | streptograminy |
Finnish | Streptogramiinit |
French | Streptogramine, Streptogramines, Synergystines |
Russian | STREPTOGRAMINY, СТРЕПТОГРАМИНЫ |
Japanese | ストレプトグラミン |
Italian | Steptogramina, Steptogramine |
Polish | Streptograminy |
German | Streptogramine |
Portuguese | Estreptograminas |
Ontology: Synercid (C0526512)
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C062940 |
English | Synercid, synercid |