II. Indications: Severe Gram Positive Infections
- Vancomycin-resistant Enterococcus
- Methicillin susceptible Staphylococcus aureus
- Methicillin susceptible Streptococcus Pyogenes
III. Mechanism
- Bacterial 50S Ribosome
- Resistance rare
IV. Pharmacokinetics
- Hepatic Clearance predominates
- Half-Life: 1-3 hours (9-10 hours of affect)
VI. Drug Interactions: Metabolized by Cytochrome P-450 3A4
- Raises serum drug levels of substrates in 3A4 system
- Follow Cyclosporine levels when using concurrently
VII. Dosing
- Enterococcus faecium: 7.5 mg/kg IV q8 hours
- Severe Skin Infections: 7.5 mg/kg IV q12 hours