Quinupristin-Dalfopristin

Aka: Quinupristin-Dalfopristin, Synercid, Streptogramin

advertisement

II. Indications: Severe Gram Positive Infections

  1. Vancomycin-resistant Enterococcus
  2. Methicillin susceptible Staphylococcus aureus
  3. Methicillin susceptible Streptococcus Pyogenes

III. Mechanism

  1. Bacterial 50S Ribosome
  2. Resistance rare

IV. Pharmacokinetics

  1. Hepatic clearance predominates
  2. Half-life: 1-3 hours (9-10 hours of affect)

V. Adverse Effects

  1. Arthralgias or myalgias
  2. Nausea, Diarrhea or Vomiting
  3. Rash or Pruritus
  4. Headache

VI. Drug Interactions: Metabolized by Cytochrome P-450 3A4

  1. Raises serum drug levels of substrates in 3A4 system
  2. Follow Cyclosporine levels when using concurrently

VII. Dosing

  1. Enterococcus faecium: 7.5 mg/kg IV q8 hours
  2. Severe Skin Infections: 7.5 mg/kg IV q12 hours

VIII. References

  1. Allington (2001) Clin Ther 23(1):24-44 [PubMed]
  2. Lamb (1999) Drugs 58(6):1061-97 [PubMed]
  3. Lundstrom (2000) Infect Dis Clin North Am 14(2):463-74 [PubMed]
  4. Manzella (2001) Am Fam Physician 64(11):1863-6 [PubMed]
  5. Paradisi (2001) Med Clin North Am 85(1):1-17 [PubMed]

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Quinupristin-Dalfopristin." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Studies

Ontology: Streptogramins (C0205997)

Definition (MSH) A class of natural cyclic peptide antibiotics produced by certain subspecies of STREPTOMYCES. They include two structurally unrelated components, STREPTOGRAMIN GROUP A and STREPTOGRAMIN GROUP B, which generally act synergistically to inhibit bacterial growth.
Concepts Antibiotic (T195) , Amino Acid, Peptide, or Protein (T116)
MSH D025361
SnomedCT 420946006, 422292008
English Streptogramins, Streptogramin, Streptogramin (product), Streptogramin (substance), Streptogramins [Chemical/Ingredient], streptogramin, streptogramins
Spanish estreptogramina (producto), estreptogramina (sustancia), estreptogramina, Estreptograminas
Swedish Streptograminer
Czech streptograminy
Finnish Streptogramiinit
French Streptogramine, Streptogramines, Synergystines
Russian STREPTOGRAMINY, СТРЕПТОГРАМИНЫ
Japanese ストレプトグラミン
Italian Steptogramina, Steptogramine
Polish Streptograminy
German Streptogramine
Portuguese Estreptograminas
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Synercid (C0526512)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C062940
English Synercid, synercid
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

advertisement

2022 Family Practice Notebook, LLC. Terms | Privacy | About | Site Map | Blog

Footer Site Logo