II. Indications: Severe Gram Positive Infections

III. Mechanism

  1. Bacterial 50S Ribosome
  2. Resistance rare

IV. Pharmacokinetics

  1. Hepatic Clearance predominates
  2. Half-Life: 1-3 hours (9-10 hours of affect)

V. Adverse Effects

  1. Arthralgias or myalgias
  2. Nausea, Diarrhea or Vomiting
  3. Rash or Pruritus
  4. Headache

VI. Drug Interactions: Metabolized by Cytochrome P-450 3A4

  1. Raises serum drug levels of substrates in 3A4 system
  2. Follow Cyclosporine levels when using concurrently

VII. Dosing

  1. Enterococcus faecium: 7.5 mg/kg IV q8 hours
  2. Severe Skin Infections: 7.5 mg/kg IV q12 hours

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