II. Indications
- Erysipeloid
- Pneumococcal Infections
- Streptococcal Infections
- Acute Necrotizing Ulcerative Gingivitis (ANUG or Vincent's Stomatitis)
- Neurosyphilis
- Congenital Syphilis
- Diphtheria
III. Contraindications
IV. ` Penicillin or Procaine Allergy
- Do NOT inject intravenously
V. Mechanism
- See Penicillin
- See Natural Penicillin for activity spectrum
VI. Precautions
- Largely replaced by other agents due to Antibiotic Resistance
- Listed for historical purposes
VII. Dosing
-
Erysipeloid, Pneumococcal Infections, Streptococcal Infections and ANUG
- Adult (or weight >27 kg): 0.6 to 1 Million Units IM daily
- Child (weight <27 kg)
- Give 0.3 Million Units IM daily OR
- Give 25,000 to 50,000 units/kg/day IM divided in 1-2 doses for moderate infections in age >1 month
-
Diphtheria
- Adult (and weight >10 kg): 0.6 Million units IM every 12 hours until transition to oral Penicillin VK for 14 days
- Child (weight <10 kg): 0.3 Million units IM every 12 hours until transition to oral Penicillin VK for 14 days
-
Neurosyphilis (Adult)
- Give 2.4 Million Units IM daily WITH Probenacid 500 mg every 6 hours for 10 to 14 days
-
Congenital Syphilis (Child)
- Give 50,000 units/kg IM daily for 10 days
VIII. Pharmacokinetics
- Peaks in 4 hours
- Duration: 24 hours
IX. Adverse Effects
- See Penicillin
X. Safety
- Considered safe in pregnancy
- Considered safe in Lactation
XI. Resources
- Procaine Penicillin (DailyMed)
XII. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 104-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
- Bush (2016) Cold Spring Harb Perspect Med 6(8):a025247 +PMID: 27329032 [PubMed]
- Miller (2002) J Midwifery Womens Health 47(6):426-34 +PMID: 12484664 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
Definition (NCI) | The procaine salt form of penicillin G, a broad-spectrum, beta-lactam, naturally occurring penicillin antibiotic with antibacterial activity. Penicillin G binds to and inactivates the penicillin binding proteins (PBPs) located inside the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis. |
Definition (MSH) | Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | D010402 |
SnomedCT | 387246005, 449005 |
LNC | LP16334-2, MTHU019826 |
English | Benzylpenicillin Procaine, Penicillin, Procaine, Procaine Penicillin, Procaine, Benzylpenicillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1), monohydrate, G Procaine, Penicillin, Procaine, Penicillin G, PROCAINE PENICILLIN G, penicillin G procaine (medication), Procaine benzylpenicillin, penicillin G procaine, procaine penicillin, Penicillin G Procaine (obsolete), Penicillin G Procaine, PENICILLIN G PROCAINE, Penicillin G Procaine [Chemical/Ingredient], penicillin g procaine, penicillin procaine, procaine penicillin g, Procaine Penicillin G, (2S,5R,6R)-3,3-Dimethyl-7-Oxo-6-(2-Phenylacetamido)-4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid Compound with 2-(Diethylamino)Ethyl p-Aminobenzoate (1:1) Monohydrate, procaine benzylpenicillin, 4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid, 3,3-Dimethyl-7-Oxo-6-((Phenylacetyl)Amino)-, (2S-(2Alpha,5Alpha,6Beta))-, Compd. with 2-(Diethylamino)Ethyl 4-Aminobenzoate (1:1) Monohydrate, APPG, Aqueous procaine penicillin G, Benzylpenicillin procaine, Penicillin G procaine, Procaine penicillin, Procaine penicillin G, Penicillin G procaine (product), Penicillin G procaine (substance) |
Swedish | Penicillin G, prokain |
Czech | prokain-penicilin G |
Finnish | Prokaiinipenisilliini |
Russian | BENZILPENITSILLINA NOVOKAINOVAIA SOL', PENITSILLIN G NOVOKAINOVYI, БЕНЗИЛПЕНИЦИЛЛИНА НОВОКАИНОВАЯ СОЛЬ, ПЕНИЦИЛЛИН G НОВОКАИНОВЫЙ |
Japanese | プロカインペニシリンG, ペニシリンGプロカイン, ベンジルペニシリンプロカイン, ペニシリンG-プロカイン |
Spanish | bencilpenicilina (sustancia), bencilpenicilina, bencilpenicilina procaína, penicilina G procaína (producto), penicilina G procaína (sustancia), penicilina G procaína acuosa, penicilina G procaína, Penicilina G Procaína |
French | Procaïne pénicilline G, Procaïne de benzylpénicilline, Procaïne de pénicilline G, Procaïne pénicilline, Pénicilline G procaïne, Benzylpénicilline procaïne |
Polish | Penicylina prokainowa |
German | Penicillin G, Procain-, Procainpenicillin |
Italian | Penicillina G procaina |
Portuguese | Penicilina G Procaína |