II. Indications

III. Contraindications

IV. ` Penicillin or Procaine Allergy

  1. Do NOT inject intravenously

V. Mechanism

  1. See Penicillin
  2. See Natural Penicillin for activity spectrum

VI. Precautions

  1. Largely replaced by other agents due to Antibiotic Resistance
  2. Listed for historical purposes

VII. Dosing

  1. Erysipeloid, Pneumococcal Infections, Streptococcal Infections and ANUG
    1. Adult (or weight >27 kg): 0.6 to 1 Million Units IM daily
    2. Child (weight <27 kg)
      1. Give 0.3 Million Units IM daily OR
      2. Give 25,000 to 50,000 units/kg/day IM divided in 1-2 doses for moderate infections in age >1 month
  2. Diphtheria
    1. Adult (and weight >10 kg): 0.6 Million units IM every 12 hours until transition to oral Penicillin VK for 14 days
    2. Child (weight <10 kg): 0.3 Million units IM every 12 hours until transition to oral Penicillin VK for 14 days
  3. Neurosyphilis (Adult)
    1. Give 2.4 Million Units IM daily WITH Probenacid 500 mg every 6 hours for 10 to 14 days
  4. Congenital Syphilis (Child)
    1. Give 50,000 units/kg IM daily for 10 days

VIII. Pharmacokinetics

  1. Peaks in 4 hours
  2. Duration: 24 hours

IX. Adverse Effects

X. Safety

  1. Considered safe in pregnancy
  2. Considered safe in Lactation

XII. References

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Ontology: penicillin G procaine (C0030830)

Definition (NCI) The procaine salt form of penicillin G, a broad-spectrum, beta-lactam, naturally occurring penicillin antibiotic with antibacterial activity. Penicillin G binds to and inactivates the penicillin binding proteins (PBPs) located inside the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
Definition (MSH) Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D010402
SnomedCT 387246005, 449005
LNC LP16334-2, MTHU019826
English Benzylpenicillin Procaine, Penicillin, Procaine, Procaine Penicillin, Procaine, Benzylpenicillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1), monohydrate, G Procaine, Penicillin, Procaine, Penicillin G, PROCAINE PENICILLIN G, penicillin G procaine (medication), Procaine benzylpenicillin, penicillin G procaine, procaine penicillin, Penicillin G Procaine (obsolete), Penicillin G Procaine, PENICILLIN G PROCAINE, Penicillin G Procaine [Chemical/Ingredient], penicillin g procaine, penicillin procaine, procaine penicillin g, Procaine Penicillin G, (2S,5R,6R)-3,3-Dimethyl-7-Oxo-6-(2-Phenylacetamido)-4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid Compound with 2-(Diethylamino)Ethyl p-Aminobenzoate (1:1) Monohydrate, procaine benzylpenicillin, 4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid, 3,3-Dimethyl-7-Oxo-6-((Phenylacetyl)Amino)-, (2S-(2Alpha,5Alpha,6Beta))-, Compd. with 2-(Diethylamino)Ethyl 4-Aminobenzoate (1:1) Monohydrate, APPG, Aqueous procaine penicillin G, Benzylpenicillin procaine, Penicillin G procaine, Procaine penicillin, Procaine penicillin G, Penicillin G procaine (product), Penicillin G procaine (substance)
Swedish Penicillin G, prokain
Czech prokain-penicilin G
Finnish Prokaiinipenisilliini
Russian BENZILPENITSILLINA NOVOKAINOVAIA SOL', PENITSILLIN G NOVOKAINOVYI, БЕНЗИЛПЕНИЦИЛЛИНА НОВОКАИНОВАЯ СОЛЬ, ПЕНИЦИЛЛИН G НОВОКАИНОВЫЙ
Japanese プロカインペニシリンG, ペニシリンGプロカイン, ベンジルペニシリンプロカイン, ペニシリンG-プロカイン
Spanish bencilpenicilina (sustancia), bencilpenicilina, bencilpenicilina procaína, penicilina G procaína (producto), penicilina G procaína (sustancia), penicilina G procaína acuosa, penicilina G procaína, Penicilina G Procaína
French Procaïne pénicilline G, Procaïne de benzylpénicilline, Procaïne de pénicilline G, Procaïne pénicilline, Pénicilline G procaïne, Benzylpénicilline procaïne
Polish Penicylina prokainowa
German Penicillin G, Procain-, Procainpenicillin
Italian Penicillina G procaina
Portuguese Penicilina G Procaína