II. Indications
III. Mechanism
IV. Medications
- Capsules: 300 mg
- Suspension: 125 to 250 mg/5ml
V. Dosing
- Adult (and age >13 years)
- Take 300 mg orally twice daily or 600 mg orally once daily
- Child (age <13 years old)
- Give 14 mg/kg/day divided once to twice daily
-
Renal Dosing
- eGFR <30 ml/min
- Adult: Limit to 300 mg/day
- Child: Limit to 7 mg/kg/day (max 300 mg/day)
- Hemodialysis: Give renal dose after Dialysis every 48 hours
- eGFR <30 ml/min
VI. Safety
- Pregnancy Category B
- Safe in Lactation
VII. Drug Interactions
-
Iron (including Multivitamins with iron)
- Take Cefdinir at least 2 hours before or 2 hours after
-
Antacids
- Take Cefdinir at least 2 hours before or 2 hours after
VIII. Resources
- Cefdinir Capsule (DailyMed)
- Cefdinir Powder for Suspension (DailyMed)
IX. References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
- (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
Images: Related links to external sites (from Bing)
Related Studies
cefdinir (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
CEFDINIR 125 MG/5 ML SUSP | Generic | $0.15 per ml |
CEFDINIR 250 MG/5 ML SUSP | Generic | $0.17 per ml |
CEFDINIR 300 MG CAPSULE | Generic | $0.44 each |
Ontology: cefdinir (C0060405)
Definition (NCI) | A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefdinir inhibits bacterial septum and cell wall synthesis formation. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C056814 |
SnomedCT | 108677001, 370366006 |
LNC | LP19960-1, MTHU011339 |
English | 7-(2 (2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid, cefdinir, CFDN, cefdinir (medication), CEFDINIR, cefdinir [Chemical/Ingredient], Cefdinir (substance), Cefdinir product (product), Cefdinir product, Cefdinir |
Spanish | producto con cefdinir (producto), cefdinir (producto), producto con cefdinir, cefdinir (sustancia), cefdinir |
Ontology: Omnicef (C0285868)
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C056814 |
English | Omnicef, cefdinir (Omnicef), omnicef, Abbott brand of cefdinir |