Doripenem

Aka: Doripenem, Doribax

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II. Indications

  1. See Carbapenem
  2. Primarily used in severe aerobic Gram-Negative Bacterial infections
    1. Complicated Urinary Tract Infections including Pyelonephritis
    2. Complicated intraabdominal infections
  3. Avoid in Bacterial Pneumonia (increased mortality)
  4. Doripenem may have greater Pseudomonas activity than other Carbapenems
    1. Otherwise similar spectrum of activity as Imipenem Cilastin and Meropenem

III. Mechanism

  1. See Carbapenem

IV. Dosing

  1. Adult Dosing
    1. Give 500 mg IV every 8 hours for 5 to 14 days
  2. Renal Dosing
    1. CrCl 30-50 ml/min: 250 mg IV every 8 hours
    2. CrCl 10-30 ml/min: 250 mg IV every 12 hours

V. Drug Interactions

  1. See Carbapenem

VI. Adverse Effects

  1. See Carbapenem

VII. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

VIII. Resources

  1. Doripenem (DailyMed)
    1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022106s008lbl.pdf

IX. References

  1. LiverTox (2017), accessed online 1/2/2023
    1. https://www.ncbi.nlm.nih.gov/books/NBK548705/
  2. Hamilton (2020) Tarascon Pharmacopeia
  3. (2012) Presc Lett, Resource #231205, Comparison of Carbapenem Antibiotics
  4. Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]

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