II. Indications
- Tapeworm infections (Hydatid Disease, Neurocysticercosis)
III. Contraindications
- Pregnancy
IV. Mechanism
V. Medications
- Albendazole Tablet 200 mg
- Tablet may be crushed or chewed
VI. Dosing: FDA Approved Indications
-
Hydatid Disease (Echinococcus)
- Weight <60 kg: 15 mg/kg/day (up to 800 mg) orally divided twice daily with food
- Weight >60 kg: 400 mg orally twice daily with food
-
Neurocysticercosis
- Take 15 mg/kg/day (up to 1200 mg) orally divided twice daily with food for 10 to 14 days
- Corticosteroid started before treatment
- Multidrug regimens (e.g. with Praziquantel) are used when more than 2 CNS Lesions are present
VII. Dosing: Unapproved Indications
VIII. Adverse Effects
- Serious
- Bone Marrow suppression
- Increased Liver Function Tests
IX. Monitoring
- Check Complete Blood Count and Liver Function Tests at start and again every 2 weeks
X. Safety
- Unknown safety in Lactation
- Contraindicated in pregnancy first trimester (unknown safety in later pregnancy)
XI. Resources
- Albendazole Tablet (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
albendazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
ALBENDAZOLE 200 MG TABLET | Generic | $13.95 each |
Ontology: Albendazole (C0001911)
Definition (NCI) | A broad-spectrum, synthetic benzimidazole-derivative anthelmintic. Albendazole interferes with the reproduction and survival of helminths by inhibiting the formation of microtubules from tubulin. This leads to an impaired uptake of glucose, a depletion of glycogen stores, and results in the worm's death. Albendazole is used in the treatment of dog and pork tapeworm-causing diseases, including hydatid disease and neurocysticercosis. Albendazole may also be used to treat a variety of other roundworm infections. (NCI05) |
Definition (MSH) | A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D015766 |
SnomedCT | 391723002, 387558006, 96119002 |
English | Albendazole, Carbamic acid, (5-(propylthio)-1H-benzimidazol-2-yl)-, methyl ester, Carbamic Acid,(5-(Propylthio)-1H-benzimidazol-2-yl)-, Methyl Ester, Proftril, albendazole, albendazole (medication), ALBENDAZOLE, Albendazole [Chemical/Ingredient], Albendazole - chemical (substance), Albendazole - chemical, Albendazole (product), Albendazole (substance) |
Swedish | Albendazol |
Czech | albendazol |
Finnish | Albendatsoli |
Russian | ALBENDAZOL, АЛБЕНДАЗОЛ |
Japanese | アルベンダゾール |
Polish | Albendazol |
Spanish | albendazol (producto), albendazol (sustancia), albendazol, Albendazol |
French | Albendazole |
German | Albendazol |
Italian | Albendazolo |
Portuguese | Albendazol |