II. Indications
III. Mechanism
- See Third Generation Broad-Spectrum Cephalosporin
- Good activity Gram Positive organisms
- Covers Staphylococcus aureus
- Covers Pneumococcus
IV. Medications
- Suspension: 50 or 100 mg/5ml
- Stable for 14 days in refrigerator
- Tablets: 100 or 200 mg
- Take with food
V. Dosing
- Adult (and age >=12 years)
- Streptococcal Pharyngitis, Simple Urinary Tract Infection
- Take 100 mg orally twice daily
- Acute Exacerbation of Chronic Bronchitis, Community Acquired Pneumonia, Acute Sinusitis
- Take 200 mg orally twice daily
- Skin Infection
- Take 400 mg orally twice daily
- Streptococcal Pharyngitis, Simple Urinary Tract Infection
- Child (age <12 years)
- Give 5 mg/kg/dose orally twice daily
-
Renal Dosing
- eGFR <30 ml/min
- Decrease dosing frequency to every 24 hours
-
Hemodialysis
- Give after Hemodialysis 3 times per week
- eGFR <30 ml/min
VI. Safety
- Pregnancy Category B
- Safe in Lactation
VII. Drug Interactions
-
Antacids (reduce absorption)
- Take Cefpodoxime at least 2 hours before or 2 hours after
VIII. Resources
IX. References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
- (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
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Related Studies
| cefpodoxime (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CEFPODOXIME 100 MG TABLET | Generic | $2.11 each |
| CEFPODOXIME 200 MG TABLET | Generic | $2.66 each |