IV. Medications

  1. Suspension: 50 or 100 mg/5ml
    1. Stable for 14 days in refrigerator
  2. Tablets: 100 or 200 mg
    1. Take with food

V. Dosing

  1. Adult (and age >=12 years)
    1. Streptococcal Pharyngitis, Simple Urinary Tract Infection
      1. Take 100 mg orally twice daily
    2. Acute Exacerbation of Chronic Bronchitis, Community Acquired Pneumonia, Acute Sinusitis
      1. Take 200 mg orally twice daily
    3. Skin Infection
      1. Take 400 mg orally twice daily
  2. Child (age <12 years)
    1. Give 5 mg/kg/dose orally twice daily
  3. Renal Dosing
    1. eGFR <30 ml/min
      1. Decrease dosing frequency to every 24 hours
    2. Hemodialysis
      1. Give after Hemodialysis 3 times per week

VI. Safety

  1. Pregnancy Category B
  2. Safe in Lactation

VII. Drug Interactions

  1. Antacids (reduce absorption)
    1. Take Cefpodoxime at least 2 hours before or 2 hours after

IX. References

  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  2. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins

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Related Studies

Cost: Medications

cefpodoxime (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CEFPODOXIME 100 MG TABLET Generic $2.11 each
CEFPODOXIME 200 MG TABLET Generic $2.66 each

Ontology: cefpodoxime (C0055011)

Definition (NCI) A third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C053268
SnomedCT 387534007, 96049003
LNC LP15210-5, MTHU003033
English 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-, cefpodoxime, CEFPODOXIME, Cefpodoxime, Cefpodoxime (product), Cefpodoxime (substance)
Spanish cefpodoxima (producto), cefpodoxima (sustancia), cefpodoxima

Ontology: Vantin (C0724204)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C053267
English Vantin, vantin