Platelet Dysfunction

Aka: Platelet Dysfunction, Platelet Bleeding Disorder, Thrombasthenia

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II. Signs

  1. Bleeding Disorders
  2. Purpura or Petechiae

III. Causes: Congenital Platelet Dysfunction

  1. Von Willebrand's Disease
  2. Glanzmann's Thrombasthenia (Autosomal Recessive)
    1. Platelet membrane deficiency Glycoprotein IIb, IIIa
    2. Defective binding of platelet Fibrinogen
    3. Decreased Platelet aggregation
  3. Bernard-Soulier Disease (Autosomal Recessive)
    1. Platelet membrane deficiency Glycoprotein Ib
    2. Coagulation Factor X and Factor V deficiency
    3. Large Platelets and decreased Platelet aggregation
  4. Storage Pool Disease
    1. Dense granule and/or alpha granule deficiency
    2. Defective Platelet release of ADP and Serotonin

IV. Causes: Acquired Platelet Dysfunction

  1. See Drug Induced Platelet Dysfunction
  2. See Thrombocytopenia
    1. Idiopathic Thrombocytopenic Purpura
    2. Thrombotic Thrombocytopenic Purpura
  3. Uremia
  4. Chronic Liver Disease

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Related Topics in Platelet Disorders

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