IV. Causes: Common by Timing

VI. Causes: Pregnancy

  1. Preeclampsia with HELLP Syndrome
  2. Acute Fatty Liver of Pregnancy
    1. Rare third trimester disorder presenting with Abdominal Pain, Nausea, Vomiting and Altered Mental Status
  3. Gestational Thrombocytopenia
    1. Benign condition in second half of pregnancy
    2. Accounts for 80% of Thrombocytopenia in pregnancy (Platelet Count >80k)
    3. Distinguish from mild immune Thrombocytopenia

VIII. Causes: Decreased Platelet Production

  1. Acquired
    1. Infiltrative process
      1. Leukemia
      2. Histiocytosis
      3. Lymphoma
      4. Myelodysplastic Syndrome
      5. Myelofibrosis
      6. Storage disease
      7. Neuroblastoma
      8. Granulomatosis
      9. Osteopetrosis
    2. Suppression of Megakaryocytes (or Bone Marrow failure)
      1. Alcohol Abuse
      2. Radiation
      3. Infection
        1. Fetal TORCH Virus infection
        2. Cytomegalovirus
        3. Epstein-Barr Virus (Mononucleosis)
        4. Varicella Zoster Virus
        5. Hepatitis C virus
        6. HIV Infection
        7. Parvovirus B19
        8. Rickettsia (includes Rocky Mountain Spotted Fever)
      4. Tick Borne Illness
        1. Rocky Mountain Spotted Fever
        2. Anaplasmosis
        3. Ehrlichiosis
        4. Babesiosis
        5. Colorado Tick Fever
      5. Paroxysmal Nocturnal Hemoglobinuria
      6. Scwachman-Diamond Syndrome
      7. Aplastic Anemia
      8. Medications
        1. See Drug induced Thrombocytopenia
        2. Alkylating Agents
        3. Antimetabolites
        4. Anticonvulsants
        5. Hydrochlorothiazide or other Thiazide Diuretics
        6. Estrogen
  2. Hereditary
    1. Alport Syndrome
    2. Bernard-Soulier Syndrome
    3. Thrombocytopenia-absent radii (TAR syndrome)
      1. Autosomal Recessive trait
      2. Purpura immediately or within weeks of birth
    4. Fanconi Anemia
    5. Wiskott-Aldrich syndrome (x-linked condition)
      1. Decreased Platelets (Microthrombocytopenia)
        1. Adequate Megakaryocytes in Bone Marrow
      2. Eczematous Dermatitis
      3. Repeated infection (Immunodeficiency)
    6. May-Hegglin anomaly
      1. Increased Megakaryocytes
      2. Ineffective thrombopoiesis
    7. Congenital amegakaryocytic Thrombocytopenia
      1. Rare isolated newborn Thrombocytopenia

IX. Causes: Platelet sequestration and miscellaneous causes

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