Reactive Thrombocytosis

Aka: Reactive Thrombocytosis, Secondary Thrombocytosiss, Reactive Thrombocythemia

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II. Epidemiology

  1. Accounts for >80% Thrombocytosis cases

III. Causes

  1. Hematologic Disorders
    1. Severe Hemorrhage
    2. Iron Deficiency Anemia
    3. Hemophilia
    4. Hemolysis
    5. Sickle Cell Anemia
    6. Recovery after Thrombocytopenia
  2. Asplenia (transient)
    1. Post Splenectomy
    2. Hyposplenia or Functional Asplenia
  3. Drugs
    1. Epinephrine
    2. Vincristine (and other Chemotherapy)
    3. Beta Lactams and other Antibiotics
    4. Corticosteroids
    5. Low Molecular Weight Heparin
    6. Tretinoin
  4. Lifestyle
    1. Alcohol Abuse
    2. Smoking
    3. Obesity
  5. Inflammatory conditions
    1. Acute infection (viral, Bacterial, fungal) - acute recovery phase
    2. Acute Pancreatitis
    3. Small Bowel Obstruction
    4. Inflammatory Bowel Disease
    5. Rheumatologic Disorders
    6. Acute Trauma (e.g. Burn Injury, Fractures)
    7. Surgery
  6. Miscellaneous
    1. Malignancy (hematologic or solid tumor)
    2. Cirrhosis
    3. Nephrotic Syndrome

IV. References

  1. Williams (2026) Am Fam Physician 113(4): 332-8 [PubMed]

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