III. Contraindications

  1. Recent major bleeding

IV. Mechanism

  1. Inhibits Platelet aggregation via Glycoprotein IIb/IIIa receptors on Platelet plasma membranes
  2. Inhibits Fibrinogen binding to Platelets

V. Dosing

  1. Non-ST elevation Myocardial Infarction (NSTEMI)
    1. Load: 25 mcg/kg over 5 min
    2. Infuse: 0.15 mcg/kg/min for up to 18 hours
      1. Slow rate to 0.075 mcg/kg/min if GFR <=60 ml/min

VI. Safety

  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation

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