II. Indications

  1. Cutaneous T Cell Lymphoma (Stage 1A and 1B)

III. Mechanism

  1. See Alkylating Agent
  2. Synthetic, nitrogen mustard Alkylating Agents used as a topical antineoplastic
  3. As with other Alkylating Agents, cross-binds DNA, blocking cell replication and other cellular functions

IV. Medications

  1. Topical Mechlorethamine (Valchlor): 0.016% Topical Gel

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Dermatitis
  2. Secondary Malignancy (non-melanoma Skin Cancer)

VII. Safety

  1. Avoid in Lactation
  2. Avoid in Pregnancy (all trimesters)
    1. Use reliable Contraception

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Ontology: Mechlorethamine (C0025033)

Definition (NCI) A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
Definition (MSH) A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.
Definition (CSP) group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen; formerly used as toxicants and vesicants, but now used therapeutically as antineoplastic agents; they are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
Definition (CSP) antineoplastic cytotoxic alkylating agent of the nitrogen mustard group.
Concepts Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D008466
SnomedCT 13154009, 387071000, 29156002, 372692002
English Bis(2-chloroethyl)methylamine, Chlorethazine, Chlormethine, Mechlorethamine, Methylchlorethamine, Mustine, Nitrogen Mustard, mechlorethamine, Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, HN2, HN<sub>2</sub>, chlorethazine, methylchlorethamine, Chloramin, NH2, Mustard, HN 2, chloromethine, ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl, Methylbis(beta-chloroethyl)amine, Mechlorethamine [Chemical/Ingredient], nh2, chlormethine, MECHLORETHAMINE, mustine, Nitrogen mustard, HN>2<, Mechlorethamine (product), Mechlorethamine (substance), nitrogen mustard, NH-2, NM
Swedish Mekloretamin
Czech mechlorethamin
Finnish Mekloretamiini
German Bis-(2-chlorethyl)-methylamin, Chlorethazin, Chlormethin, Mechlorethamin, Mustin, Stickstofflost
Russian KHLORETAZIN, MEKHLORETAMIN, AZOTISTYI IPRIT, KHLORMETIN, MEKHLORETAMINOKSID, N-OKSID AZOTISTOGO IPRITA, MUSTIN, N-ОКСИД АЗОТИСТОГО ИПРИТА, АЗОТИСТЫЙ ИПРИТ, МЕХЛОРЭТАМИН, МЕХЛОРЭТАМИНОКСИД, МУСТИН, ХЛОРМЕТИН, ХЛОРЭТАЗИН
Japanese 酸化メクロレタミン, ナイトロジェンマスタードN酸化物, ムスチン, メクロレタミン, ナイトロジェンマスタード, クロレタジン, クロルメチン, ニトロジェンマスタード, ニトロジェンマスタードN酸化物
Croatian MEKLORETAMIN
Polish N-tlenek iperytu azotowego, Chlormetyna
Spanish clorhidrato de mecloretamina (sustancia), mecloretamina (producto), mecloretamina (sustancia), mecloretamina, mostaza nitrogenada, mustina, Cloretazina, Clormetina, Mecloretamina, Mostaza Nitrogenada, Mustina
French Chlorméthine
Italian Mecloretamina
Portuguese Cloretazina, Clormetina, Mecloretamina, Mostarda Nitrogenada, Mustina