II. Indications

  1. Cutaneous T Cell Lymphoma (Stage 1A and 1B)

III. Mechanism

  1. See Alkylating Agent
  2. Synthetic, nitrogen mustard Alkylating Agents used as a topical antineoplastic
  3. As with other Alkylating Agents, cross-binds DNA, blocking cell replication and other cellular functions

IV. Medications

  1. Topical Mechlorethamine (Valchlor): 0.016% Topical Gel

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Dermatitis
  2. Secondary Malignancy (non-melanoma Skin Cancer)

VII. Safety

  1. Avoid in Lactation
  2. Avoid in Pregnancy (all trimesters)
    1. Use reliable Contraception

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