II. Indications
- Cutaneous T Cell Lymphoma (Stage 1A and 1B)
III. Mechanism
- See Alkylating Agent
- Synthetic, nitrogen mustard Alkylating Agents used as a topical antineoplastic
- As with other Alkylating Agents, cross-binds DNA, blocking cell replication and other cellular functions
IV. Medications
- Topical Mechlorethamine (Valchlor): 0.016% Topical Gel
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Dermatitis
- Secondary Malignancy (non-melanoma Skin Cancer)
VII. Safety
- Avoid in Lactation
- Avoid in Pregnancy (all trimesters)
- Use reliable Contraception
VIII. Resources
- Mechlorethamine (DailyMed)