Definition (NCI)
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A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
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Definition (MSH)
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A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.
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Definition (CSP)
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group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen; formerly used as toxicants and vesicants, but now used therapeutically as antineoplastic agents; they are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
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Definition (CSP)
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antineoplastic cytotoxic alkylating agent of the nitrogen mustard group.
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Concepts |
Pharmacologic Substance
(T121)
, Hazardous or Poisonous Substance
(T131)
, Organic Chemical
(T109)
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MSH |
D008466
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SnomedCT |
13154009, 387071000, 29156002, 372692002 |
English |
Bis(2-chloroethyl)methylamine, Chlorethazine, Chlormethine, Mechlorethamine, Methylchlorethamine, Mustine, Nitrogen Mustard, mechlorethamine, Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, HN2, HN<sub>2</sub>, chlorethazine, methylchlorethamine, Chloramin, NH2, Mustard, HN 2, chloromethine, ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl, Methylbis(beta-chloroethyl)amine, Mechlorethamine [Chemical/Ingredient], nh2, chlormethine, MECHLORETHAMINE, mustine, Nitrogen mustard, HN>2<, Mechlorethamine (product), Mechlorethamine (substance), nitrogen mustard, NH-2, NM |
Swedish |
Mekloretamin
|
Czech |
mechlorethamin
|
Finnish |
Mekloretamiini
|
German |
Bis-(2-chlorethyl)-methylamin, Chlorethazin, Chlormethin, Mechlorethamin, Mustin, Stickstofflost |
Russian |
KHLORETAZIN, MEKHLORETAMIN, AZOTISTYI IPRIT, KHLORMETIN, MEKHLORETAMINOKSID, N-OKSID AZOTISTOGO IPRITA, MUSTIN, N-ОКСИД АЗОТИСТОГО ИПРИТА, АЗОТИСТЫЙ ИПРИТ, МЕХЛОРЭТАМИН, МЕХЛОРЭТАМИНОКСИД, МУСТИН, ХЛОРМЕТИН, ХЛОРЭТАЗИН |
Japanese |
酸化メクロレタミン, ナイトロジェンマスタードN酸化物, ムスチン, メクロレタミン, ナイトロジェンマスタード, クロレタジン, クロルメチン, ニトロジェンマスタード, ニトロジェンマスタードN酸化物 |
Croatian |
MEKLORETAMIN
|
Polish |
N-tlenek iperytu azotowego, Chlormetyna |
Spanish |
clorhidrato de mecloretamina (sustancia), mecloretamina (producto), mecloretamina (sustancia), mecloretamina, mostaza nitrogenada, mustina, Cloretazina, Clormetina, Mecloretamina, Mostaza Nitrogenada, Mustina |
French |
Chlorméthine
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Italian |
Mecloretamina
|
Portuguese |
Cloretazina, Clormetina, Mecloretamina, Mostarda Nitrogenada, Mustina |