II. See Also
III. Indications
- See Erythropoietin
- Anemia of Chronic Renal Failure (Hemoglobin <10 g/dl)
- Not FDA approved for use in cancer patients
IV. Contraindications
- See Erythropoietin
V. Mechanism
- See Erythropoietin
VI. Precautions
- Not a substitute for Blood Products in acute severe, symptomatic Anemia
- Avoid Hemoglobin targets above 11 g/dl (higher risk of cardiovascular and thrombotic events)
- Use the lowest effective dose
-
Iron Supplementation if needed
- Check for Iron Deficiency before administration
VII. Medications
- Available in single-dose prefilled syringes 30 to 360 mcg
VIII. Dosing: Adult
- Start 0.6 mcg/kg IV or SQ every 2 weeks
- Indicated for Hemoglobin <10 g/dl
- Stop if Hemoglobin >10 g/dl (or >11 g/dl if on Hemodialysis)
IX. Dosing: Child
- See other references (see resources below)
- Dose is based on conversion of stable Hemoglobin on other Erythropoietin product to Mircera
- Every 4 week dosing
X. Adverse Effects
- See Erythropoietin
XI. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
XII. Resources
- Methoxy Polyethyelene Glycol Epoetin Beta (DailyMed)
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Related Studies
Definition (NCI) | A pegylated form of recombinant human erythropoietin, a glycosylated protein naturally produced in the kidney that stimulates erythrocyte production in the bone marrow. Methoxypolyethylene glycol epoetin beta may reverse anemias induced by cancer therapy. (NCI04) |
Definition (NCI_NCI-GLOSS) | A substance that is being studied in the treatment of anemia in patients who are receiving chemotherapy. It is a form of erythropoietin (a substance produced in the kidneys that stimulates the production of red blood cells) that has been changed in the laboratory. |
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | C508420 |
SnomedCT | 426360006, 425913002 |
English | methoxy polyethylene glycol epoetin beta, Methoxy polyethylene glycol-epoetin beta (substance), Methoxy polyethylene glycol-epoetin beta (product), epoetin beta-methoxy polyethylene glycol, Methoxy polyethylene glycol-epoetin beta, METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA, Pegzerepoetin Alfa, Methoxy Polyethylene Glycol-Epoetin Beta, Methoxy Polyethylene Glycol-Epoetin beta, methoxy polyethylene glycol-epoetin beta, methoxypolyethylene glycol epoetin beta |
Spanish | metoxipolietilenglicol-epoetin beta (producto), metoxipolietilenglicol-epoetina beta (producto), metoxipolietilenglicol-epoetina beta, metoxipolietilenglicol-epoetin beta, metoxipolietilenglicol-epoetin beta (sustancia), metoxipolietilenglicol-epoetina beta (sustancia) |