II. See Also

III. Indications

  1. See Erythropoietin
  2. Anemia of Chronic Renal Failure (Hemoglobin <10 g/dl)
  3. Not FDA approved for use in cancer patients

IV. Contraindications

V. Mechanism

VI. Precautions

  1. Not a substitute for Blood Products in acute severe, symptomatic Anemia
  2. Avoid Hemoglobin targets above 11 g/dl (higher risk of cardiovascular and thrombotic events)
    1. Use the lowest effective dose
  3. Iron Supplementation if needed
    1. Check for Iron Deficiency before administration

VII. Medications

  1. Available in single-dose prefilled syringes 30 to 360 mcg

VIII. Dosing: Adult

  1. Start 0.6 mcg/kg IV or SQ every 2 weeks
  2. Indicated for Hemoglobin <10 g/dl
  3. Stop if Hemoglobin >10 g/dl (or >11 g/dl if on Hemodialysis)

IX. Dosing: Child

  1. See other references (see resources below)
  2. Dose is based on conversion of stable Hemoglobin on other Erythropoietin product to Mircera
  3. Every 4 week dosing

X. Adverse Effects

XI. Safety

  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation

XII. Resources

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Related Studies

Ontology: Methoxy polyethylene glycol-epoetin beta (C1328071)

Definition (NCI) A pegylated form of recombinant human erythropoietin, a glycosylated protein naturally produced in the kidney that stimulates erythrocyte production in the bone marrow. Methoxypolyethylene glycol epoetin beta may reverse anemias induced by cancer therapy. (NCI04)
Definition (NCI_NCI-GLOSS) A substance that is being studied in the treatment of anemia in patients who are receiving chemotherapy. It is a form of erythropoietin (a substance produced in the kidneys that stimulates the production of red blood cells) that has been changed in the laboratory.
Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116)
MSH C508420
SnomedCT 426360006, 425913002
English methoxy polyethylene glycol epoetin beta, Methoxy polyethylene glycol-epoetin beta (substance), Methoxy polyethylene glycol-epoetin beta (product), epoetin beta-methoxy polyethylene glycol, Methoxy polyethylene glycol-epoetin beta, METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA, Pegzerepoetin Alfa, Methoxy Polyethylene Glycol-Epoetin Beta, Methoxy Polyethylene Glycol-Epoetin beta, methoxy polyethylene glycol-epoetin beta, methoxypolyethylene glycol epoetin beta
Spanish metoxipolietilenglicol-epoetin beta (producto), metoxipolietilenglicol-epoetina beta (producto), metoxipolietilenglicol-epoetina beta, metoxipolietilenglicol-epoetin beta, metoxipolietilenglicol-epoetin beta (sustancia), metoxipolietilenglicol-epoetina beta (sustancia)