II. See Also
III. Indications
- See Erythropoietin
- Anemia of Chronic Renal Failure (Hemoglobin <10 g/dl)
- Not FDA approved for use in cancer patients
IV. Contraindications
- See Erythropoietin
V. Mechanism
- See Erythropoietin
VI. Precautions
- Not a substitute for Blood Products in acute severe, symptomatic Anemia
- Avoid Hemoglobin targets above 11 g/dl (higher risk of cardiovascular and thrombotic events)
- Use the lowest effective dose
-
Iron Supplementation if needed
- Check for Iron Deficiency before administration
VII. Medications
- Available in single-dose prefilled syringes 30 to 360 mcg
VIII. Dosing: Adult
- Start 0.6 mcg/kg IV or SQ every 2 weeks
- Indicated for Hemoglobin <10 g/dl
- Stop if Hemoglobin >10 g/dl (or >11 g/dl if on Hemodialysis)
IX. Dosing: Child
- See other references (see resources below)
- Dose is based on conversion of stable Hemoglobin on other Erythropoietin product to Mircera
- Every 4 week dosing
X. Adverse Effects
- See Erythropoietin
XI. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
XII. Resources
- Methoxy Polyethyelene Glycol Epoetin Beta (DailyMed)