II. Indications
- Metastatic Breast Cancer (refractory)
- Metastatic Liposarcoma (refractory, non-resectable)
III. Mechanism
- See Mitotic Inhibitor Chemotherapy
- Eribulin is a Halichondrin B analog with antineoplastic properties
- Dervied from the marine sponge Lissodendoryx.
- Eribulin is an anti-tubulin agent
- Binds to tubulin (at vinca doman)
- Inhibits tubulin polymerization and microtubule assembly
- Arrests Cell Cycle at G2/M phase
IV. Medications
- Eribulin 1 mg/2ml intravenous solution
V. Dosing
- See other references for disease specific dosing protocols
- Adjust dosing in renal and hepatic Impairment
- Adults: 1.4 mg/m2 on days 1 and 8, in every 21 day cycles
VI. Adverse Effects
VII. Pharmacokinetics
- Hepatic excretion in feces unchanged
VIII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
IX. Resources
- Eribulin Injection Solution (DailyMed)
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Related Studies
| Definition (NCI) | An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. |
| Definition (NCI_NCI-GLOSS) | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitubulin agents. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C490954 |
| English | Halichondrin B Analog, 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one, Eribulin, eribulin, 2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one, ERIBULIN, halichrondrin B analog |
| Japanese | エリブリン |
