II. Definitions

  1. Liposarcoma
    1. Rare malignant lesion similar to Lipoma
    2. Located in Retroperitoneum, Shoulders, and legs (esp. thighs)

III. Epidemiology

  1. Responsible for 17% of all Soft Tissue Sarcomas
  2. Most common age 50 to 60 years old
  3. Equal gender distribution between men and women
  4. Rare in children
    1. Consider lipoblastoma instead in young children

IV. Symptoms

  1. Painless, rapidly expanding Soft Tissue Mass

V. Signs

  1. Asymmetric, typically mobile non-tender swelling
  2. Evaluate for proximal Lymphadenopathy

VI. Imaging

  1. XRay
    1. Soft Tissue Mass
  2. MRI
    1. Findings vary based on grade and subtype
    2. Larger, well differentiated tumors may show nodular nonadipose tissue islands

VII. Management

  1. Refer to orthopedic oncology for core needle biopsy and surgical resection

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Ontology: liposarcoma (C0023827)

Definition (NCI) A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Representative morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid/round cell liposarcoma. The metastatic potential is higher in less differentiated tumors.
Definition (NCI_CDISC) A malignant neoplasm composed of adipose tissue.
Definition (MSH) A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)
Definition (CSP) malignant tumor derived from primitive or embryonal lipoblastic cells; may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid, round-celled, or pleomorphic, usually in association with a rich network of capillaries; recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces.
Concepts Neoplastic Process (T191)
MSH D008080
ICD10 M8850/3
SnomedCT 49430005, 189777004, 254829001
English Liposarcoma, Liposarcomas, Liposarcoma NOS, [M]Liposarcoma NOS, liposarcoma (diagnosis), Liposarcoma, no ICD-O subtype, Liposarcoma [Disease/Finding], liposarcomas, Liposarcomas malignant, [M]Liposarcoma NOS (morphologic abnormality), Liposarcoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality), Liposarcoma, no International Classification of Diseases for Oncology subtype, Liposarcoma, no ICD-O subtype (morphologic abnormality), LIPOSARCOMA, MALIGNANT, Fibroliposarcoma, Liposarcoma morphology, Liposarcoma (disorder), Liposarcoma, NOS, Liposarcoma (morphologic abnormality), liposarcoma
Italian Liposarcomi maligni, Liposarcoma NAS, Liposarcoma
Dutch liposarcoom NAO, liposarcomata maligne, liposarcoom, Liposarcoom, Sarcoom, lipo-
French Liposarcome SAI, Liposarcomes malins, Liposarcome
German Liposarkom NNB, Liposarkome boesartig, Liposarkom
Portuguese Lipossarcoma NE, Liposarcomas malignos, Liposarcoma, Lipossarcoma
Spanish Liposarcoma NEOM, liposarcoma, no clasificado como subtipo en CIE-O (anomalía morfológica), liposarcoma, no clasificado como subtipo en CIE-O, [M]liposarcoma, SAI (anomalía morfológica), [M]liposarcoma, SAI, fibroliposarcoma, liposarcoma (anomalía morfológica), liposarcoma (trastorno), liposarcoma, SAI, liposarcoma, morfología de liposarcoma, Liposarcomas malignos, Liposarcoma
Japanese 脂肪肉腫, 悪性脂肪肉腫, 脂肪肉腫NOS, アクセイシボウニクシュ, シボウニクシュ, シボウニクシュNOS
Swedish Liposarkom
Czech liposarkom, Liposarkom, Liposarkomy maligní, Liposarkom NOS
Finnish Liposarkooma
Russian LIPOSARKOMA, ЛИПОСАРКОМА
Croatian LIPOSARKOM
Polish Tłuszczak mięsakowy, Tłuszczakomięsak
Hungarian Liposarcoma k.m.n., Liposarcoma, Liposarcomak, rosszindulatú
Norwegian Liposarkom