II. Dosing: Prophylactic Dose
-
Creatinine Clearance (CrCl) >30 ml/min AND Weight 40-150 kg
- Enoxaparin (Lovenox) 40 mg SQ daily
-
Creatinine Clearance (CrCl) >30 ml/min AND Weight >150 kg (or BMI 40 of higher)
- Enoxaparin (Lovenox) 40 mg SQ twice daily
-
Creatinine Clearance (CrCl) 15-30 ml/min (or weight <40 kg)
- Enoxaparin (Lovenox) 30 mg SQ daily
-
Creatinine Clearance (CrCl) <15 ml/min
- Enoxaparin (Lovenox) is contraindicated
- Use unfractionated heaprin 5000 units SQ every 8-12 hours
III. Dosing: Therapeutic Dose
-
Creatinine Clearance (CrCl) >30 ml/min
- Enoxaparin (Lovenox) 1 mg/kg SQ every 12 hours
-
Creatinine Clearance (CrCl) 15-30 ml/min (or weight <40 kg)
- Unfractionated Heparin is preferred
- As an alternative, Enoxaparin (Lovenox) 1 mg/kg SQ once daily for up to 7 days
-
Creatinine Clearance (CrCl) <15 ml/min
- Enoxaparin (Lovenox) is contraindicated
- Use unfractionated heaprin 5000 units SQ every 8-12 hours
IV. References
- Dummer (2009) Perioperative Guidelines
- Douketis (2008) Chest 133(6 Suppl):299S-339S [PubMed]
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| ENOXAPARIN 100 MG/ML SYRINGE | Generic | $10.14 per ml |
| ENOXAPARIN 120 MG/0.8 ML SYR | Generic | $17.75 per ml |
| ENOXAPARIN 150 MG/ML SYRINGE | Generic | $16.75 per ml |
| ENOXAPARIN 30 MG/0.3 ML SYR | Generic | $12.43 per ml |
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| ENOXAPARIN 80 MG/0.8 ML SYR | Generic | $10.14 per ml |