Definition (CHV)
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a kind of cancer treatment drug
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Definition (CHV)
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a kind of cancer treatment drug
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Definition (CHV)
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a kind of cancer treatment drug
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Definition (NCI_NCI-GLOSS)
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An anticancer drug that is a type of antitumor antibiotic.
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Definition (NCI)
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A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
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Definition (MSH)
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A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
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Definition (PDQ)
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A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39675&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39675&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C412" NCI Thesaurus)
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Concepts |
Antibiotic
(T195)
, Amino Acid, Peptide, or Protein
(T116)
|
MSH |
D003609
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SnomedCT |
360183007, 387353003, 64127001 |
English |
Actinomycin D, Dactinomycin, Meractinomycin, 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3, Actinomycin IV, Actinomycin I1, Actinomycin X 1, Dactinomycine, Actinomycin A IV, actinomycin-C1, Actinomycin-[thr-val-pro-sar-meval], actinomycin-D (medication), actinomycin-D, dactinomycin (medication), DACTINOMYCIN, Dactinomycin [Chemical/Ingredient], actinomycin d, actinomycin-d, DACTINomycin, dactinomycin, Dactinomycin - chemical (substance), Dactinomycin - chemical, ACTINOMYCIN D, Dactinomycin product, Dactinomycin (product), Dactinomycin (substance), actinomycin D, ACT-D, AD, actinomycin C1, DACT, Actinomycin C1 |
Swedish |
Daktinomycin
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Czech |
daktinomycin
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Finnish |
Daktinomysiini
|
French |
Actinomycine C1, Actinomycine D, Dactinomycine |
Russian |
AKTINOMITSIN D, AKTINOMITSINY, DAKTINOMITSIN, AKTINOMITSIN, MERAKTINOMITSIN, АКТИНОМИЦИН D, АКТИНОМИЦИН, АКТИНОМИЦИНЫ, ДАКТИНОМИЦИН, МЕРАКТИНОМИЦИН |
Japanese |
アクチノマイシンC1, ダクチノマイシン, メラクチノマイシン, アクチノマイシンD, アクチノマイシン |
Italian |
Meractinomicina, Actinomicina D, Dactinomicina |
Croatian |
AKTINOMICIN D, DAKTINOMICIN |
Polish |
Meraktynomycyna, Daktynomycyna, Aktynomycyna |
Spanish |
dactinomicina - compuesto químico (sustancia), dactinomicina - compuesto químico, actinomicina D, dactinomicina (producto), dactinomicina (sustancia), dactinomicina, Actinomicina D, Dactinomicina, Meractinomicina |
German |
Actinomycin D, Dactinomycin, Meractinomycin |
Portuguese |
Actinomicina D, Dactinomicina, Meractinomicina |