Definition (NCI)
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Any monoclonal antibody directed against the cell surface glycoprotein CD52, regardless of the antibody type (e.g., rat, mouse, humanized).
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Definition (NCI)
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A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein, CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 + cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A type of monoclonal antibody used in the treatment of leukemia. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.
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Definition (PDQ)
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A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein, CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 + cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37783&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37783&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1681" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Immunologic Factor
(T129)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
C096529
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SnomedCT |
391632007, 129472003 |
English |
Monoclonal Antibody CD52, MoAb CD52, anti-CD52 monoclonal antibody, alemtuzumab (medication), Anti-CD52 Monoclonal Antibody, Anti-CD52 Antibody, ALEMTUZUMAB, Alemtuzumab (Obsolete), alemtuzumab [Chemical/Ingredient], alemtuzumab, LDP-03, Alemtuzumab (product), Alemtuzumab (substance), Alemtuzumab |
Spanish |
alemtuzumab (producto), alemtuzumab (sustancia), alemtuzumab |