Definition (NCI_NCI-GLOSS)
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An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease).
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Definition (NCI)
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A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)
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Definition (MSH)
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A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
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Definition (PDQ)
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A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39506&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39506&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C664" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D008939
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SnomedCT |
255662000, 26288002, 404865004 |
LNC |
LP18384-5, MTHU004186 |
English |
Mytotan, o,p-DDD, ortho,para-DDD, Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-, ortho,para DDD, 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, 2,4'-Dichlorodiphenyldichloroethane, 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane, 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene, mitotane, Ortho,para-DDD, DDD O P, ORTHO PARA DDD, mitotane (medication), o,P'-DDD, o,P'-DDD (medication), Mitotane [Chemical/Ingredient], 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, 2, 4'-Dichlorodiphenyldichloroethane, Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-, (o,p)-DDD, 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, O,p'-DDD, o,p'-DDD, op'DDD - Mitotane, 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane, Mitotane (substance), Mitotane (product), DDD, o,p' - DDD, Mitotane, MITOTANE |
Swedish |
Mitotan
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Czech |
mitotan
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Finnish |
Mitotaani
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Russian |
ORTO, PARA-DIKHLORDIFENILDIKHLORETAN, KHLODITAN, MITOTAN, O,P-DDD, МИТОТАН, ОРТО, ПАРА-ДИХЛОРДИФЕНИЛДИХЛОРЭТАН, ХЛОДИТАН |
Japanese |
ミトーテン, クロジタン, マイトテイン, ミトタン, オルトパラDDD |
German |
ORTHO PARA DDD, DDD O P, Mitotan, o,p-DDD, ortho,para-DDD |
Polish |
O,p-dwuchlorodwufenylodwuchloroetan, Mitotan |
Spanish |
1,1-dicloro-2- (o-clorofenil-2- (p-clorofenil) etano, o,p'-DDD, O,p'-DDD, mitotano (sustancia), mitotano, mitotano (producto), Mitotano, o,p-DDD, orto para-DDD |
French |
Mitotane
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Italian |
Mitotano
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Portuguese |
Mitotano, o,p-DDD, orto para-DDD |