II. Indications

III. Contraindications

  1. Liver malignancies

IV. Mechanism

  1. See Antimetabolite Chemotherapy
  2. Antineoplastic, PyrimidineNucleoside analog of cytidine
    1. By binding DNA at cytidine binding sites, Azacitidine blocks DNA methyltransferase, and in turn DNA methylation
    2. Also acts at RNA, with impaired function

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Bone Marrow Suppression
  2. Impaired future fertility

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
    2. Men should also not father children while taking Azacitidine
  3. Monitoring
    1. Complete Blood Count
    2. Renal Function tests
    3. Liver Function Tests

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