II. Indications
- Myelodysplastic Syndrome
- Acute Myelogenous Leukemia (non-severe, off-label use)
III. Contraindications
- Liver malignancies
IV. Mechanism
- See Antimetabolite Chemotherapy
- Antineoplastic, PyrimidineNucleoside analog of cytidine
- By binding DNA at cytidine binding sites, Azacitidine blocks DNA methyltransferase, and in turn DNA methylation
- Also acts at RNA, with impaired function
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Bone Marrow Suppression
- Impaired future fertility
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Men should also not father children while taking Azacitidine
- Monitoring