Definition (NCI)
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A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A substance made in the laboratory that stimulates the bone marrow to produce red blood cells. It belongs to the family of drugs called antianemics.
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Definition (PDQ)
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A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38676&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38676&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1878" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
C417052
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SnomedCT |
391638006, 385610007, 385608005 |
LNC |
LA18622-3 |
English |
Novel Erythropoiesis Stimulating Protein, darbepoetin alfa (medication), DARBEPOETIN ALFA, alfa darbepoetin, novel erythropoiesis stimulating protein, 30-l-Asparagine-32-l-threonine-87-l-valine-88-l-asparagine-90-l-threonineerythropoietin (human), darbepoietin alfa, Darbepoetin alfa (product), Darbepoetin alfa, Darbepoetin alfa #1 (substance), Darbepoetin alfa (substance), NESP, darbepoetin alfa, Darbepoetin Alfa |
Spanish |
darbepoyetina alfa - 1, darbepoyetina alfa - 1 (sustancia), darbepoetina alfa (sustancia), darbepoyetina alfa (sustancia), darbepoetin alfa, darbepoetina alfa (producto), darbepoetina alfa, darbepoyetina alfa |