II. Indications

  1. Hairy Cell Leukemia
    1. Moxetumomab pasudotox-tdfk
  2. B Cell precursor Acute Lymphoblastic Leukemia
    1. Inotuzumab Ozogamicin

III. Mechanism

  1. CD22
    1. CD22 is a B Cell lectin and adhesion molecule
    2. CD22 is involved in cell signaling and adhesion to Monocytes and T-Cells
  2. CD22 Monoclonal Antibody
    1. Conjugate antibodies that deliver cytotoxic drugs to CD22 positive cancer cells

IV. Medications

  1. Moxetumomab pasudotox-tdfk (Lumoxiti)
    1. Conjugated Monoclonal Antibody that delivers the cytotoxic drug Pseudomonas exotoxin A to cancer cells
    2. Avoid in severe Renal Insufficiency (eGFR <30 ml/min)
    3. Used in Hairy Cell Leukemia
    4. Risks of Hemolytic Uremic Syndrome, capillary leak syndrome, Nephrotoxicity, Electrolyte abnormalities
  2. Inotuzumab Ozogamicin (Besponsa)
    1. Conjugated Monoclonal Antibody that delivers the cytotoxic drug calicheamicin to cancer cells
    2. Used against B Cell precursors in Acute Lymphoblastic Leukemia
    3. Risks of hepatotoxicity and hepatic veno-occlusive disease

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects: Moxetumomab

  1. Hemolytic Uremic Syndrome
  2. Capillary leak syndrome
  3. Nephrotoxicity
    1. Obtain Renal Function testing before each dose
  4. Infusion Reaction
    1. Premedicate
  5. Electrolyte abnormalities
    1. Obtain Electrolytes before each dose and at 8 days after dose
  6. Other common adverse effects
    1. Gastrointestinal (Nausea, Diarrhea, Constipation)
    2. Headache
    3. Fever
    4. Anemia

VII. Adverse Effects: Inotuzumab

  1. Infusion Reactions
  2. QTc Prolongation
  3. Hepatotoxicity
    1. Includes hepatic veno-occlusive disease (sinusoidal obstruction)
    2. Increased transaminases, GGT, and Serum Bilirubin
  4. Myelosuppression
    1. Thrombocytopenia
    2. Leukopenia
    3. Neutropenia
    4. Anemia
  5. Other common adverse effects
    1. Fever
    2. Nausea or Vomiting

VIII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters, Unknown Pregnancy category)
    1. Use reliable Contraception
  3. Monitoring
    1. Renal Function tests
    2. Serum Electrolytes (including Serum Calcium, Serum Phosphorus)
    3. Liver Function Tests (LFTs)

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Related Studies

Ontology: CD22 antigen (C0054947)

Definition (NCI) B-cell receptor CD22 (847 aa, 95 kD) is a cell adhesion process protein that is encoded by the human CD22 gene and may have a role in cell adhesion.
Definition (NCI_NCI-GLOSS) A protein found on some tumor cells.
Definition (NCI) Cell surface carbohydrate molecules of the Lewis Y or Lewis X type that are detectable with monoclonal antibody B3. This group of antigens is found more frequently on tumor cells than normal cells.
Definition (CSP) B cell specific adhesion molecule; active in adhesion to monocytes and T cells.
Definition (MSH) A lectin and cell adhesion molecule found in B-LYMPHOCYTES. It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS.
Concepts Receptor (T192) , Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D051918
SnomedCT 71797000
LNC LP64428-3, LP20041-7, LP68372-9, MTHU021831, MTHU026323
English BL-CAM, CD22 - Cluster of diff ag 22, Cluster of diff antigen 22, ANTIGENS CD 022, CD 022 ANTIGENS, LYMPHOCYTE CELL ADHESION MOLECULE B, B-Cell Receptor CD22, CD22 molecule, Leu 14, B3 Antigen, Sialic Acid Binding Ig like Lectin 2, Antigens, CD22, Sialic Acid Binding Ig-like Lectin 2, Sialic Acid Binding Ig-like Lectin 2 [Chemical/Ingredient], CD22 Ag, B3 antigen, Lymphocyte antigen CD22, CD22 - Cluster of differentiation antigen 22, Cluster of differentiation antigen 22, Leucocyte 14, Leukocyte 14, Lymphocyte antigen CD22 (substance), CD22 antigen, CD22, Lyb8, B-Cell Antigen CD22, Sialic Acid-Binding Immunoglobulin-Like Lectin 2, B-Lymphocyte Cell Adhesion Molecule, CD22 Antigen, Antigen, CD22, B Lymphocyte Cell Adhesion Molecule, CD22 Antigens, CD22 Glycoprotein, Glycoprotein, CD22, Siglec-2
Czech antigeny CD22, molekula buněčné adheze B-lymfocytů
Finnish CD22-antigeenit
Russian ANTIGENY CD22, CD22 ANTIGENY, ИММУНОГЛОБУЛИН-ПОДОБНЫЙ ЛЕКТИН 2, СВЯЗЫВАЮЩИЙ СИАЛОВУЮ КИСЛОТУ, SIALOVUIU KISLOTU SVIAZYVAIUSHCHII IG-PODOBNYI LEKTIN 2, СИАЛОВУЮ КИСЛОТУ СВЯЗЫВАЮЩИЙ IG-ПОДОБНЫЙ ЛЕКТИН 2, IMMUNOGLOBULIN-PODOBNYI LEKTIN 2, SVIAZYVAIUSHCHII SIALOVUIU KISLOTU, GLIKOPROTEIN CD22, ГЛИКОПРОТЕИН CD22, АНТИГЕНЫ CD22, CD22 АНТИГЕНЫ
Japanese CD22糖蛋白質, 抗原CD22, CD22抗原, 抗原-CD22, B細胞接着分子, Bリンパ球細胞接着分子
Swedish CD22-antigener
French Protéine Siglec-2, Molécule d'adhésion cellulaire des lymphocytes B, Molécule d'adhérence cellulaire des lymphocytes B, Antigène CD22, CD22, Lectine-2 de type Ig liant l'acide sialique, Antigènes CD22, Glycoprotéine CD22
Polish Antygeny CD22, Lektyna 2 Ig-podobna wiążąca kwas sjalowy, Glikoproteina CD22
Italian Lectina Ig-simile legante l'acido sialico 2, Antigene CD22, Antigeni CD22
Spanish Antígenos CD22, Lectina 2 Similar a Ig de Unión al Ácido Siálico, antígeno linfocitario CD22 (sustancia), antígeno linfocitario CD22, Molécula de Adhesión Celular de los Linfocitos B
Portuguese Lectina 2 Semelhante a Ig de Ligação ao Ácido Siálico, Antígenos CD22, Lectina 2 Similar a Ig de Ligação ao Ácido Siálico, Lectina 2 Similar a Imunoglobulina de Ligação ao Ácido Siálico, Lectina 2 Semelhante a Ig Ligante de Ácido Siálico, Lectina 2 Similar a Ig Ligante de Ácido Siálico, Lectina 2 Similar a Imunoglobulina Ligante de Ácido Siálico, Lectina 2 Semelhante a Imunoglobulina de Ligação ao Ácido Siálico, Lectina 2 Semelhante a Imunoglobulina Ligante de Ácido Siálico, Molécula de Adesão Celular do Linfócito B
German Antigene, CD22-, B-Lymphozyten-Zelladhäsionsmolekül, CD22-Antigene, CD22-Antigen, CD22-Glykoprotein, Siglec-2