II. Mechanism

III. Indications

  1. Atrial Fibrillation Anticoagulation
  2. Deep Vein Thrombosis
    1. However, must be started concurrently with Heparin, unlike other Factor Xa Inhibitors (Apixaban, Rivaroxaban)

IV. Contraindications

  1. Creatinine Clearance <15 ml/min/1.73m2
  2. Creatinine Clearance >95 ml/min/1.73m2 (lower efficacy due to high drug clearance)
  3. Severe Cirrhosis (Child-Pugh Class C)

V. Dosing

  1. Standard dose: 60 mg orally daily
  2. Half dose indications (30 mg orally daily)
    1. Creatinine Clearance 15 to 50 ml/min/1.73m2 OR
    2. Weight <60 kg

VI. Pharmacokinetics

  1. Oral Bioavailability: 62%
  2. Half-Life: 10-14 hours
  3. Onset: 1-2 hours
  4. Renal Clearance 50%

VIII. Safety

  1. Unknown Safety in Pregnancy
  2. Unknown Safety in Lactation

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Cost: Medications

savaysa (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SAVAYSA 60 MG TABLET $12.46 each