II. Indications
- Myelosuppressive Chemotherapy-Induced Neutropenia
- Acute Radiation Syndrome related myelosuppression
III. Mechanism
- Granulocyte Colony-Stimulating Factor (G-CSF)
- Endogenous Cytokine that modulates the production, differentiation and function Neutrophilic Granulocyte progenitors
- G-CSF is endogenously produced by Monocytes, fibroblasts, and endothelial cells
- G-CSF activates Granulocyte production via binding specific cell surface receptors
- Pegfilgrastim
- Pegfilgrastim is a recombinant, synthetic agent similar to the B isoform of G-CSF
- Like G-CSF, Pegfilgrastim stimulates the production of Neutrophils
- Used to counter Neutropenia secondary to anticancer drug induced myelosuppression
- Pegfilgrastim is the pegylated (conjugated to Polyethylene Glycol) form of Filgrastim
- Pegylation significantly increases the Half-Life of Filgrastim
- Pegfilgrastim is a recombinant, synthetic agent similar to the B isoform of G-CSF
IV. Precautions
- Do NOT give 14 days before or 24 hours after cytotoxic/myelosuppressive Chemotherapy
- Unknown risk of cytotoxic agents on rapidly dividing myeloid cells
- Storage
- Store medication in refrigerator
- Use within 48 hours when at room Temperature
- Protect from light exposure
V. Dosing: Adult
- See other references for specific dosing
- Myelosuppressive Chemotherapy-Induced Neutropenia
- Give 6 mg SQ once per Chemotherapy cycle
-
Acute Radiation Syndrome related myelosuppression
- Give 6 mg SQ for 2 doses, 1 week apart
VI. Dosing: Child
- Weight-Based Dosing
- Weight <10 kg: 0.1 mg/kg
- Weight 10 to 20 kg: 1.5 mg
- Weight 21 to 30 kg: 2.5 mg
- Weight 31 to 44 kg: 4.0 mg
- Weight >=45 kg: Use adult dosing as above
- Myelosuppressive Chemotherapy-Induced Neutropenia
- Give weight-based dose SQ once per Chemotherapy cycle
-
Acute Radiation Syndrome related myelosuppression
- Give weight-based dose SQ for 2 doses, 1 week apart
VII. Adverse Effects
- Medullary bone pain
- Allergic Reaction
- Cutaneous Vasculitis
VIII. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
IX. Resources
- Pegfilgrastim (DailyMed)
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Related Studies
Definition (NCI_NCI-GLOSS) | A drug used to increase numbers of white blood cells in patients who are receiving chemotherapy. It is a type of colony-stimulating factor. |
Definition (NCI) | A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04) |
Definition (PDQ) | A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37807&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37807&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1854" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
MSH | C455861 |
SnomedCT | 388379009, 385544005 |
English | SD-01 sustained duration G-CSF, Filgrastim SD-01, SD-01, colony-stimulating factors pegfilgrastim, pegfilgrastim (medication), PEGFILGRASTIM, pegfilgrastim [Chemical/Ingredient], N-(3-HYDROXYPROPYL)METHIONYLCOLONY-STIMULATING FACTOR (HUMAN), 1-ETHER WITH .ALPHA.-METHYL-.OMEGA.-HYDROXYPOLY(OXYETHYLENE), pegfilgrastim, filgrastim-SD/01, Pegfilgrastim (product), Pegfilgrastim (substance), Pegfilgrastim, GCSF-SD01, PEG-rmetHuG-CSF, PEG SD-01, SD-01, polyethylene glycol-conjugated filgrastim, SD-01-filgrastim |
Spanish | pegfilgrastim (producto), pegfilgrastim (sustancia), pegfilgrastim |