II. Indications

  1. FDA Approved
    1. Hodgkin Lymphoma
    2. Melanoma (metastatic)
  2. Off-Label
    1. Medullary Thyroid Cancer
    2. Panceatic Neuroendocrine Masses
    3. Pheochromocytoma (malignant)
    4. Soft Tissue Sarcoma

III. Mechanism

  1. See Alkylating Agent
  2. Triazene derived antineoplastic
    1. Prodrug that is metabolized in the liver to the active MTIC (monomethyl triazeno imidazole carboxamide)
    2. Similar to Temozolomide, which is metabolized to MTIC at physiologic pH
  3. Acts as an DNA Alkylating Agent, cross-linking DNA and blocking cell function and replication

IV. Dosing

  1. See other references for disease specific dosing protocols

V. Adverse Effects

  1. Alopecia
  2. Bone Marrow Suppression
  3. Gastrointestinal (Nausea, Vomiting, Anorexia)
  4. Hepatotoxicity
  5. Secondary Malignancy
  6. Soft Tissue Injury on extravasation
    1. May result in severe local tissue necrosis

VI. Safety

  1. Avoid in Lactation
  2. Avoid in Pregnancy (all trimesters)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests

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Related Studies

Ontology: Dacarbazine (C0010927)

Definition (CHV) a kind of cancer treatment drug
Definition (CHV) a kind of cancer treatment drug
Definition (CHV) a kind of cancer treatment drug
Definition (NCI) A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
Definition (NCI_NCI-GLOSS) A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.
Definition (MSH) An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
Definition (CSP) cytotoxic alkylating agent used as an antineoplastic primarily for treatment of malignant melanoma and in combination chemotherapy for Hodgkin's disease and sarcomas; administered intravenously; abbreviated DTIC.
Definition (PDQ) A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39768&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39768&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C411" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D003606
SnomedCT 387441003, 77750008
English Carboxamide, Dimethyl Imidazole, Dacarbazine, Decarbazine, DIC, Dimethyl Imidazole Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, DTIC, ICDT, Imidazole Carboxamide, Dimethyl, dacarbazine, 1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-, 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide, 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-, 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide, 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide, 5-(dimethyltriazeno)imidazole-4-carboxamide, Dacarbazine - DTIC, Dakarbazin, Imidazole Carboxamide Dimethyltriazeno, Dacarbazina, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, dimethyltriazenoimidazole carboxamide, dacarbazine (medication), DACARBAZINE, Dacarbazine [Chemical/Ingredient], Dacarbazine (DTIC), dtic, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Dimethyl-triazeno-imidazole carboxamide, DIC - Dacarbazine, DTIC - Dacarbazine, Dacarbazine (product), Dacarbazine (substance), dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide
Swedish Dakarbazin
Czech dakarbazin
Finnish Dakarbatsiini
Russian DAKARBAZIN, DTIC, ДАКАРБАЗИН
Italian DIC, Decarbazina, Dimetil-triazeno-imidazol-carbossamide, Dimetil imidazolo carbossamide, ICDT, DTIC, Dacarbazina
Spanish Dacarbazina, Dacarbacina, dacarbazina (producto), dacarbazina (sustancia), dacarbazina, dimetil-triazeno-imidazol carboxamida, DTIC
Polish Dakarbazyna, DTIC
French Dacarbazine
German DTIC, Dacarbazin
Portuguese DTIC, Dacarbazina