II. Indications

  1. FDA Approved
    1. Hodgkin Lymphoma
    2. Melanoma (metastatic)
  2. Off-Label
    1. Medullary Thyroid Cancer
    2. Panceatic Neuroendocrine Masses
    3. Pheochromocytoma (malignant)
    4. Soft Tissue Sarcoma

III. Mechanism

  1. See Alkylating Agent
  2. Triazene derived antineoplastic
    1. Prodrug that is metabolized in the liver to the active MTIC (monomethyl triazeno imidazole carboxamide)
    2. Similar to Temozolomide, which is metabolized to MTIC at physiologic pH
  3. Acts as an DNA Alkylating Agent, cross-linking DNA and blocking cell function and replication

IV. Dosing

  1. See other references for disease specific dosing protocols

V. Adverse Effects

  1. Alopecia
  2. Bone Marrow Suppression
  3. Gastrointestinal (Nausea, Vomiting, Anorexia)
  4. Hepatotoxicity
  5. Secondary Malignancy
  6. Soft Tissue Injury on extravasation
    1. May result in severe local tissue necrosis

VI. Safety

  1. Avoid in Lactation
  2. Avoid in Pregnancy (all trimesters)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests

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