II. Preparations: Cryoprecipitate
- Derived from thawing Fresh Frozen Plasma and collecting precipitate
- Contains 50 ml/unit
- Contains high concentrations of Fibrinogen
- Contains high concentrations of Factor VIII
- Also contains Factors V, XIII, vWF
III. Indications: Adults
- Post-cardiac surgery Hemorrhage (or other postoperative bleeding)
- Postpartum Hemorrhage
- Gastrointestinal Bleeding
- Massive Hemorrhage or Massive Transfusion Protocol
- Hypofibrinogenemia (Fibrinogen <100-200 mg/dl)
- As an alternative to Cryoprecipitate, Fibrinogen replacement may be given in Massive Hemorrhage
IV. Indications: Newborns
- Factor VIII Deficiency (if recombinant Factor VIII not available)
- Von Willebrand Disease (if recombinant factors not available)
- Factor XIII deficiency
- Congenital Dysfibrinogenemia
- Congenital Fibrinogen deficiency
V. Labs: Fibrinogen
- Increases Fibrinogen up to 100 mg/dl per dose (15-20 ml per 5-7 kg body weight, or 10 units for 70 kg)
- Expect one unit to raise Fibrinogen 5-10 mg/dl
- Goal Fibrinogen >100 mg/dl
VI. Dosing
- Adults: 15-20 ml per 5-7 kg body weight
- Typical dose: 10 units Cryoprecipitate
- Newborn: variable dosing starting from 2 ml/kg