II. Indications

  1. T Cell Acute Lymphoblastic Leukemia or Lymphoma (relapse or refractory)

III. Mechanism

  1. Purine Antimetabolite (arabinonucleoside) with antineoplastic activity
  2. Nelarabine is demethoxylated by Adenosine deaminase to its biologically active metabolite, Ara-G
    1. Ara-G (9-beta-D-arabinosylguanine) incorporates into DNA
    2. Inhibits DNA synthesis

IV. Medications

  1. Nelarabine IV Solution: 5 mg/ml in 50 ml vials

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Myelosuppression
  2. Neurotoxicity
    1. Altered Mental Status
    2. Demyelination (rare)
    3. Headache
    4. Paralysis
    5. Peripheral Neuropathy
    6. Seizures
    7. Somnolence

VII. Safety

  1. Avoid in Pregnancy (any trimester)
    1. Use reliable Contraception
  2. Avoid in Lactation
  3. Monitoring
    1. Renal Function Tests

Images: Related links to external sites (from Bing)

Related Studies

Ontology: nelarabine (C0907349)

Definition (NCI_NCI-GLOSS) A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.
Definition (NCI) An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)
Definition (PDQ) An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43260&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43260&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1704" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C104457
SnomedCT 418538001, 418784008
English 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, 2-Amino, 6-Methoxypurine Arabinoside, 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, nelarabine (medication), NELARABINE, nelarabine [Chemical/Ingredient], 2-Amino-6-methoxypurine arabinoside, 2-amino-6-methoxypurine arabinoside, nelarabine, Nelarabine, Nelarabine (product), Nelarabine (substance)
Spanish nelarabina (producto), nelarabina (sustancia), nelarabina