II. Indications
- T Cell Acute Lymphoblastic Leukemia or Lymphoma (relapse or refractory)
III. Mechanism
IV. Medications
- Nelarabine IV Solution: 5 mg/ml in 50 ml vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Myelosuppression
- Neurotoxicity
- Altered Mental Status
- Demyelination (rare)
- Headache
- Paralysis
- Peripheral Neuropathy
- Seizures
- Somnolence
VII. Safety
- Avoid in Pregnancy (any trimester)
- Use reliable Contraception
- Avoid in Lactation
- Monitoring
- Renal Function Tests