II. Indications
- T Cell Acute Lymphoblastic Leukemia or Lymphoma (relapse or refractory)
III. Mechanism
IV. Medications
- Nelarabine IV Solution: 5 mg/ml in 50 ml vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Myelosuppression
- Neurotoxicity
- Altered Mental Status
- Demyelination (rare)
- Headache
- Paralysis
- Peripheral Neuropathy
- Seizures
- Somnolence
VII. Safety
- Avoid in Pregnancy (any trimester)
- Use reliable Contraception
- Avoid in Lactation
- Monitoring
- Renal Function Tests
VIII. Resources
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Related Studies
Definition (NCI_NCI-GLOSS) | A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites. |
Definition (NCI) | An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04) |
Definition (PDQ) | An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43260&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43260&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1704" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
MSH | C104457 |
SnomedCT | 418538001, 418784008 |
English | 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, 2-Amino, 6-Methoxypurine Arabinoside, 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, nelarabine (medication), NELARABINE, nelarabine [Chemical/Ingredient], 2-Amino-6-methoxypurine arabinoside, 2-amino-6-methoxypurine arabinoside, nelarabine, Nelarabine, Nelarabine (product), Nelarabine (substance) |
Spanish | nelarabina (producto), nelarabina (sustancia), nelarabina |