Coagulation Bleeding Disorder

Aka: Coagulation Bleeding Disorder, Blood Coagulation Disorder, Coagulation Disorder, Coagulopathy

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II. Pathophysiology

  1. See Bleeding Disorder
  2. See Clotting Pathway
  3. Images
    1. ThrombosisPathway.png

III. Causes: Congenital Coagulopathy (Severe Hereditary Bleeding Disorders)

  1. Hemophilia A (Factor VIII Deficiency, 85% of Hemophilia cases)
  2. Hemophilia B (Factor IX Deficiency, 15% of Hemophilia cases)
  3. Von Willebrand's Disease

IV. Causes: Acquired Coagulopathy

  1. Vitamin K Deficiency
  2. Cirrhosis (decrease of both coagulant and Anticoagulant factors)
  3. End Stage Renal Disease (Anemia, Platelet Dysfunction)
  4. Disseminated Intravascular Coagulation (DIC)
  5. Fibrinogen deficiency
    1. L-Asparaginase therapy
    2. Rattlesnake bite
  6. Clotting Factor deficiency
  7. Circulating Anticoagulant
    1. Lymphoma
    2. Systemic Lupus Erythematosus (SLE)
    3. Idiopathic
  8. Massive Transfusion (Dilutional Coagulopathy)

V. Signs: Presentations

  1. See Bleeding Disorder
  2. Hemophilia A or B often presents with bleeding complications shortly after birth
    1. Cephalohematoma or Intracranial Hemorrhage
    2. Significant bleeding from Circumcision site
  3. Other common presentations
    1. Gingival Bleeding
    2. Minor Trauma with significant bleeding or large Hematomas
    3. Severe Menorrhagia (common delayed presentation in Von Willebrand's Disease)

VI. References

  1. Jones (2024) Am Fam Physician 110(1): 58-64 [PubMed]

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