II. Causes: Congenital Coagulopathy (Severe Hereditary Bleeding Disorders)
- Hemophilia A (Factor VIII Deficiency, 85% of Hemophilia cases)
- Hemophilia B (Factor IX Deficiency, 15% of Hemophilia cases)
- Von Willebrand's Disease
III. Causes: Acquired Coagulopathy
- Vitamin K Deficiency
- Cirrhosis (decrease of both coagulant and Anticoagulant factors)
- End Stage Renal Disease (Anemia, Platelet Dysfunction)
- Disseminated Intravascular Coagulation (DIC)
-
Fibrinogen deficiency
- L-Asparaginase therapy
- Rattlesnake bite
- Clotting Factor deficiency
- Circulating Anticoagulant
- Lymphoma
- Systemic Lupus Erythematosus (SLE)
- Idiopathic
- Massive Transfusion (Dilutional Coagulopathy)
IV. Signs: Presentations
- See Bleeding Disorder
-
Hemophilia A or B often presents with bleeding complications shortly after birth
- Cephalohematoma or Intracranial Hemorrhage
- Significant bleeding from Circumcision site
- Other common presentations
- Gingival Bleeding
- Minor Trauma with significant bleeding or large Hematomas
- Severe Menorrhagia (common delayed presentation in Von Willebrand's Disease)