II. Labs: Characteristics

  1. Shares common appearance with other Staphylococci
    1. Gram Positive Cocci in irregular clusters
    2. Facultative Anaerobes
    3. Beta hemolytic
      1. As with Beta Hemolytic Streptococcus, hemolyze RBCs on sheep blood agar plate (BAL)
    4. Catalase positive
      1. Catalase converts Hydrogen Peroxide (from Macrophages, PMNs) into water and oxygen
      2. Catalase positive organisms on a culture plate will bubble when exposed to Hydrogen Peroxide
  2. Unique Staphylococcus Epidermidis features
    1. Coagulase-Negative Organisms
      1. Contrast with the coagulase positive Staphylococcus Aureus
    2. Adherent Polysaccharide capsule
      1. Polysaccharide capsule adheres well to catheters and prosthethic devices
      2. Most common colonizer of tubes and devices (and related secondary infections)
      3. Staphylococcus Epidermidis commonly forms a biofilm around these devices

III. Pathophysiology

  1. Normal Bacterial colonization of human skin
    1. Frequently contaminates Blood Cultures
  2. Infects catheters and lines
    1. Catheter Associated Urinary Tract Infection
    2. Central Line-Associated Bloodstream Infection
  3. Prosthetic Infections
    1. Prosthetic Joint Infection
    2. Prosthetic Valve Endocarditis
    3. Peritoneal Dialysis Catheter Infections

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Ontology: Staphylococcus epidermidis (C0038174)

Definition (NCI) A species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for catalase, urease, and alkaline phosphatase and negative for coagulase and oxidase. It can ferment glucose, fructose, maltose, sucrose, glycerol, mannose, lactose, and turanose but not arabinose, mannitol, xylose, cellobiose, xylitol, rhamnose or trehalose. S. epidermidis is a commensal human skin organism and can be a human pathogen causing sepsis or endocarditis in patients with implants or immunocompromised individuals.
Definition (NCI_CDISC) Any bacterial organism that can be assigned to the species Staphylococcus epidermidis.
Definition (MSH) A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.
Definition (CSP) species of Staphylococcus that is a spherical, nonmotile, gram positive, chemoorganotrophic, facultative anaerobe; mainly found on the skin and mucous membrane of warm blooded animals, it can be primary pathogen or secondary invader.
Concepts Bacterium (T007)
MSH D013212
SnomedCT 60875001
LNC LP102548-7
Swedish Staphylococcus epidermidis
English STAPH EPIDERMIDIS, S. epidermidis, s. epidermidis, staphylococcus epidermidis albus, staphylococcus albus, staphylococcus epidermidis, Staphylococcus epidermidis (Winslow and Winslow 1908) Evans 1916, Staphylococcus epidermidis, Albococcus epidermidis, Micrococcus epidermidis, STAPHYLOCOCCUS EPIDERMIDIS, STAPHYLOCOCCUS ALBUS, Staphylococcus albus, Micrococcus pyogenes var. albus, Staphylococcus epidermidis albus, Staphylococcus epidermidis (organism)
Czech Staphylococcus epidermidis
Finnish Staphylococcus epidermidis
Russian STAFILOKOKK EPIDERMAL'NYI, СТАФИЛОКОКК ЭПИДЕРМАЛЬНЫЙ
Croatian STAPHYLOCOCCUS EPIDERMIDIS
Polish Staphylococcus epidermidis, Gronkowiec naskórkowy
Norwegian Staphylococcus epidermidis
Spanish Micrococcus pyogenes, variedad albus, Staphylococcus epidermidis (organismo), Staphylococcus epidermidis
French Staphylococcus epidermidis
German Staphylococcus epidermidis
Italian Staphylococcus epidermidis
Dutch Staphylococcus epidermidis
Portuguese Staphylococcus epidermidis