II. Indications
- Primary Series (Immunization Schedule in Children)
-
Immunocompromised State
- Immunocompromised state requires additional Hib doses (esp. if age 12 to 59 months)
- Conditions required additional Hib Vaccine doses (see CDC guidelines)
- Chemotherapy or Radiation Therapy
- Hematopoietic Stem Cell Transplant
- Anatomic Asplenia or Functional Asplenia (e.g. Sickle Cell Anemia)
- Elective Splenectomy
- HIV Infection
- Immunoglobulin Deficiency or Early component complement deficiency
III. Mechanism
- Hib is a conjugated protein Vaccine
- Haemophilus Influenzae PRP Capsule Protein (Polyribitol Ribose Phosphate)
- Conjugated to one of the following immunogenic Proteins (activate T Lymphocytes)
- Mutated Diphtheria toxin Protein
- Neisseria Meningitidis outer membrane Protein
- Tetanus Toxoid
IV. Medications
- Individual Vaccinations
- PRP-T (ActHIB or Hiberix)
- PRP-OMP (PedvaxHIB)
- Stronger immune response with first dose
- Preferred in high risk communities
- American Indian or Alaska native
- Asplenia or Immunosuppression
- Standard Combination agents (most common delivery for U.S. Primary Series)
- Other combinations (limited use)
- Hib/MenCY (Menhibrix)
V. Protocol: Primary Series
- Dose 1: Age 2 months
- Dose 2: Age 4 months
- Dose 3: Age 6 months (dose 3 is skipped if using PedvaxHIB for all other 3 doses)
- Dose 4: Age 12 to 15 months
VI. Efficacy
- See Haemophilus Influenzae
- Decreased Incidence by 99% since Hib Vaccination began in 1987 to 1989
- Previously Hib was most common cause of Meningitis and invasive disease <5 years old
VII. Adverse Effects
- No serious side effects
- Fever
- Irritability
- References
VIII. Resources
- CDC Immunization Schedules (last accessed 10/28/2020)
Images: Related links to external sites (from Bing)
Related Studies
| Concepts | Pharmacologic Substance (T121) , Immunologic Factor (T129) |
| MSH | C044237 |
| SnomedCT | 333680004, 412374001 |
| English | Haemophilus influenzae type b polysaccharide vaccine, HIB-vaccine, HIB - Hemophilus influenzae Type B vaccine, HIB vaccine, Haemophilus influenzae Type b, Hemophilus influenzae Type b, Hemophilus influenzae Type b vaccine, Haemophilus influenzae type B vaccine, Haemophilus influenzae type b polyribosylribitol phosphate capsular polysaccharide vaccine, Hemophilus influenzae type b vaccine, hib vaccine, Haemophilus influenzae Type b vaccine (product), Haemophilus influenzae Type b vaccine (substance), Haemophilus influenzae type b vaccine (substance), Haemophilus influenzae type b vaccine, HIB - Haemophilus influenzae Type B vaccine, Haemophilus influenzae Type b vaccine |
| Spanish | vacuna anti-Haemophilus influenzae tipo b (producto), vacuna anti-Haemophilus influenzae tipo b, vacuna anti-Haemophilus influenzae tipo b (sustancia) |
