II. Background
- Pneumovax 23 (PPSV23) is a purified capsular PolysaccharideAntigens from 23 serotypes
- These serotypes are responsible for 88% of invasive pneumococcal disease
- As of 2024 in U.S, PCV20 and PCV21 have replaced the use of Pneumovax 23 (PPSV23)
- Dual coverage with PPSV23 is no longer needed with PCV20 and PCV21
- Dual Immunization with PPSV23 is still needed if PCV13 or PCV15 are given
III. Dosing
- Dosing regimens are being modified in 2022 by CDC
- Prevnar 20 is sufficient alone, and does not require Pneumovax
- GIve Prevnar 20 alone (or Vaxneuvance AND Pneumovax 23)
- See Prevnar for dosing Pneumococcal Vaccine schedules
- Pneumovax 23 Indications (when Vaxneuvance or Prevnar 13 are used)
- One dose of Pneumovax 23 is sufficient for most patients at age 65 years
- Indication for single dose ages 2 to 64 years
- See Indications above
- Give a second dose at age 65 or at least 5 years after the last dose
- Indication for 2 doses at more than 5 years apart at ages 2 to 64 years
- Give third dose at age 65 years or at least 5 years after the last dose
- Chronic renal disease (Renal Failure, Nephrotic Syndrome)
- Asplenia
- Sickle Cell Anemia
- Immunocompromised state
- HIV Infection
- Leukemia
- Lymphoma
- Multiple Myeloma
- Iatrogenic (e.g. organ transplant, Radiation Therapy, Chemotherapy)
IV. Precautions
- Administer to high risk women before pregnancy
- ACIP recommends avoiding in pregnancy
-
Pneumococcal Vaccine may be given on same day as other Vaccines (e.g. Influenza Vaccine, Shingles Vaccine)
- Pneumococcal Conjugate Vaccine (e.g. PCV21) may have reduced Antibody response when given with Influenza Vaccine
- However, given both Vaccines (Prevnar and Influenza) does not reduce their efficacy
V. References
- (2024) Presc Lett 31(12): 67-8
- Presc Lett 22(11): 63
- Kobayashi (2022) MMWR Morb Mortal Wkly Rep 71(4): 109-17 [PubMed]
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Related Studies
| Concepts | Pharmacologic Substance (T121) , Immunologic Factor (T129) |
| MSH | D022242 |
| French | Pneumovax |
| English | pneumovax, Pneumovax |
Ontology: Polyvalent pneumococcal vaccine (C0305065)
| Definition (HL7V3.0) | <p>pneumococcal polysaccharide vaccine</p> |
| Definition (NCI) | An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years. |
| Concepts | Pharmacologic Substance (T121) , Immunologic Factor (T129) |
| MSH | D022242 |
| SnomedCT | 70447008, 135642004, 417011002 |
| HL7 | 109, 33 |
| English | pneumococcal polyvalent vaccine, pneumococcal polysaccharide vaccine, pneumococcal polysaccharide vaccine (medication), Pneumococcal Polysaccharide Vaccine [Chemical/Ingredient], Polysaccharide Vaccine, Pneumococcal, Vaccine, Pneumococcal Polysaccharide, PPSV, Polyvalent pneumococcal vaccine, Pneumococcal polysaccharide vaccine (product), Pneumococcal polysaccharide vaccine, Polyvalent pneumococcal vaccine (product), Polyvalent pneumococcal vaccine (substance), Pneumococcal Polyvalent Vaccine, Pneumococcal Polysaccharide Vaccine, pneumococcal, NOS, pneumococcal, Pneumococcal polysaccharide vaccine (substance), PNEUMOCOCCAL POLYSACCHARIDE VACCINE, Pneumococcal Vaccine Polyvalent |
| Czech | pneumokoková polysacharidová vakcína |
| Portuguese | Vacina de Polissacarídeo de Pneumococos |
| Spanish | Vacuna Polisacarida Neumococica, vacuna antineumocócica polisacárida (producto), vacuna antineumocócica polisacárida, vacuna antineumocócica polivalente (producto), vacuna antineumocócica polivalente (sustancia), vacuna antineumocócica polivalente, vacuna de polisacárido neumocócico (sustancia), vacuna de polisacárido neumocócico |
| French | Vaccin antipneumococcique polysaccharidique, Vaccin pneumococcique polysaccharidique |
| German | Pneumokokken-Polysaccharid-Vakzine, Pneumokokken-Polysaccharid-Impfstoff |
Ontology: Pneumovax 23 (C0947642)
| Concepts | Pharmacologic Substance (T121) , Carbohydrate (T118) , Immunologic Factor (T129) |
| English | Pneumovax 23, Pneumovax 23 (obsolete) |
