II. Indications
-
Post-exposure Prophylaxis
- See Rabies Postexposure Prophylaxis
- Given with Rabies Immunoglobulin
- Pre-Exposure Prophylaxis
- Veterinarians
- Animal control and wildlife professionals
- Lab workers
- Adventure travelers to Rabies endemic areas
- Archaeology work
III. Preparations
-
General
- All preparations in U.S. produced in cell culture
- Safer than infected animal brain preparations
- HDCV (Imovax)
- Human Diploid Cells
- Risk of Serum Sickness risk on booster doses: 6%
- RVA (Rabies Vaccine Absorbed)
- Fetal rhesus diploid lung cells
- PCEC (RabAvert)
- Developed in chick Embryo
- New preparation with fewer side effects
- Contraindicated in severe egg allergy
IV. Adverse Effects
- Mild erythema, swelling, and local pain
- Headache
- Myalgias
-
Serum Sickness (Type III) Hypersensitivity Reaction
- Seen with HDCV on booster dose
V. Protocol: Pre-Exposure Prophylaxis
- See Rabies Postexposure Prophylaxis
- Rabies Vaccine 1 ml IM deltoid days 0, 7, and 21-28
VI. Precautions
- Safe in HIV and Pregnancy