II. Indications

  1. Post-exposure Prophylaxis
    1. See Rabies Postexposure Prophylaxis
    2. Given with Rabies Immunoglobulin
  2. Pre-Exposure Prophylaxis
    1. Veterinarians
    2. Animal control and wildlife professionals
    3. Lab workers
    4. Adventure travelers to Rabies endemic areas
    5. Archaeology work

III. Preparations

  1. General
    1. All preparations in U.S. produced in cell culture
    2. Safer than infected animal brain preparations
  2. HDCV (Imovax)
    1. Human Diploid Cells
    2. Risk of Serum Sickness risk on booster doses: 6%
  3. RVA (Rabies Vaccine Absorbed)
    1. Fetal rhesus diploid lung cells
  4. PCEC (RabAvert)
    1. Developed in chick Embryo
    2. New preparation with fewer side effects
    3. Contraindicated in severe egg allergy

IV. Adverse Effects

  1. Mild erythema, swelling, and local pain
  2. Headache
  3. Myalgias
  4. Serum Sickness (Type III) Hypersensitivity Reaction
    1. Seen with HDCV on booster dose

V. Protocol: Pre-Exposure Prophylaxis

  1. See Rabies Postexposure Prophylaxis
  2. Rabies Vaccine 1 ml IM deltoid days 0, 7, and 21-28

VI. Precautions

  1. Safe in HIV and Pregnancy

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Related Studies

Ontology: Rabies Vaccines (C0034496)

Definition (HL7V3.0) <p>rabies vaccine, NOS</p>
Definition (MSH) Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.
Definition (CSP) vaccines or candidate vaccines used to prevent and/or treat rabies.
Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129) , Organic Chemical (T109)
MSH D011819
SnomedCT 333606008, 396437008
CPT 90676, 90675
HL7 90
English Rabies Human Diploid Cell Vaccine, Rabies Vaccine, Vaccine, Rabies, rabies vaccine, human diploid cell, Rabies Vaccines [Chemical/Ingredient], rabies vaccines, vaccines rabies, Vaccines, Rabies, Rabies vaccines, rabies vaccine, vaccines viral rabies, rabies vaccine (medication), rabies vaccine, human diploid, Rabies vaccine, Rabies vaccine (product), Rabies vaccine (substance), rabies, NOS, Rabies Vaccines, RABIES VACCINE
Spanish Vacunas Antirrábicas, Vacunas contra la Rabia, vacuna antirrábica (producto), vacuna antirrábica (sustancia), vacuna antirrábica
Swedish Rabiesvacciner
Czech vzteklina - vakcíny, rabies - vakcíny
Finnish Vesikauhurokotteet
Japanese 狂犬病ワクチン, ワクチン-狂犬病
Italian Vaccino rabico, Vaccino rabico su cellule umane diploidi, Vaccini rabici
Polish Szczepionki przeciw wściekliźnie
Portuguese Vacinas Antirrábicas, Vacinas contra Raiva
French Vaccins antirabiques
German Impfstoffe, Rabies-, Impfstoffe, Tollwut-, Rabiesvakzinen, Tollwutimpfstoffe, Tollwutvakzinen, Vakzinen, Rabies-, Vakzinen, Tollwut-