II. Indications
- Prevention of Vibrio Cholera O1 in adults travelling to Cholera-affected areas
III. Preparations
- Lypholized CVD 103-HgR (Vaxchora, PaxVax)
- Single dose, live attenuated, oral Cholera Vaccine
- Only FDA approved Cholera Vaccine in U.S. (approved in 2016)
- Efficacy beyond 3 months is not known as of late 2017
- Avoid use of Antibiotics in the 14 days preceding Cholera Vaccine
- Delay starting Chloroquine for at least 10 days after oral Cholera Vaccine
- Delay taking oral Typhoid Vaccine by at least 8 hours after oral Cholera Vaccine
- Likely safe in HIV Infection (but lower seroconversion rate)
- Like safe in pregnancy as no systemic absorption (however Vaccine is shed for 7 days)
- Killed Cholera Vaccine
- Older intradermal Vaccine, 0.2 ml IM given at time 0, 1-4 weeks and then every 6 months as needed
- Protection of 30-50% lasts only 6 months
- Safe in Human Immunodeficiency Virus (HIV)
- Do not use in pregnancy